Attenuation of internal organ damages by exogenously administered epidermal growth factor (EGF) in burned rodents

Major burns are associated with multiple internal organ damages, including necrosis of the gastrointestinal mucosa. Failure of the intestinal barrier is a serious complication in burned patients. Epidermal growth factor (EGF) is a mitogenic polypeptide that stimulates wound repair and affords protec...

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Bibliographic Details
Published in:Burns 2002-08, Vol.28 (5), p.435-442
Main Authors: Berlanga, Jorge, Lodos, Jorge, López-Saura, Pedro
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Biological and medical sciences
Burns
Burns - complications
Burns - pathology
Cytoprotection
Digestive System - drug effects
Digestive System - pathology
Disease Models, Animal
Emergency and intensive care: burns
Epidermal growth factor (EGF)
Epidermal Growth Factor - administration & dosage
Epidermal Growth Factor - therapeutic use
Injections, Intraperitoneal
Intensive care medicine
Male
Medical sciences
Mice
Mice, Inbred BALB C
Multiple Organ Failure - etiology
Multiple Organ Failure - pathology
Multiple Organ Failure - prevention & control
Random Allocation
Rats
Rats, Sprague-Dawley
Time Factors
Trauma Severity Indices
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Summary:Major burns are associated with multiple internal organ damages, including necrosis of the gastrointestinal mucosa. Failure of the intestinal barrier is a serious complication in burned patients. Epidermal growth factor (EGF) is a mitogenic polypeptide that stimulates wound repair and affords protection to the gastric mucosa. We examined whether a single systemic intervention with EGF prevents organ systems damages, following full-thickness scalds (25–30%) in rodents. Animals were randomly assigned to receive an intraperitoneal injection of EGF (30 μg/kg in mice, 10 μg/kg in rats) or saline solution, 30 min prior thermal injury in mice or after the cutaneous injury in rats. General clinical condition and mortality during 24 h were recorded. Animals were autopsied and histopathological and histomorphometric studies were conducted. Mice treated with EGF exhibited a milder clinical evolution and acute lethality was significantly reduced as compared to saline counterparts ( P
ISSN:0305-4179
1879-1409
DOI:10.1016/S0305-4179(02)00023-2