Growth of human squamous cell carcinoma xenografts in mice is inhibited by local angiostatin gene therapy

The possibility of inhibiting tumor growth by blocking the formation of new tumor vessels has recently received attention. Antiangiogenic tumor therapies have recently attracted intense interest because of their direct endothelial targeting and the absence of drug resistance. Local antiangiogenic ge...

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Bibliographic Details
Published in:Oral oncology 2002-09, Vol.38 (6), p.543-548
Main Authors: MATSUMOTO, G, SASAKURI, K, TSUKINOKI, K, OHMI, Y, LEE, U, SHINDO, J
Format: Article
Language:English
Subjects:
Angiostatins
Animals
Apoptosis
Biological and medical sciences
Carcinoma, Squamous Cell - blood supply
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - therapy
DNA, Complementary - genetics
Gene Expression
Gene Targeting - methods
Genetic Therapy - methods
Humans
Liposomes
Medical sciences
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Neovascularization, Pathologic - prevention & control
Otorhinolaryngology. Stomatology
Peptide Fragments - genetics
Peptide Fragments - metabolism
Plasminogen - genetics
Plasminogen - metabolism
Transfection
Transplantation, Heterologous
Tumor Cells, Cultured
Tumors
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:The possibility of inhibiting tumor growth by blocking the formation of new tumor vessels has recently received attention. Antiangiogenic tumor therapies have recently attracted intense interest because of their direct endothelial targeting and the absence of drug resistance. Local antiangiogenic gene therapy for cancer offers a potential way to achieve sustained therapeutic release of antiangiogenic substances. As a step toward this goal, we used liposomes complexed to angiostatin cDNA and targeted to human squamous cell carcinoma cell lines in vivo. Tumor cells expressing angiostatin after local gene transfer showed markedly reduced vascularity and contained many apoptotic tumor cells. These results demonstrate the potential utility of liposome-derived angiostatin for adjuvant therapy of oral cancer in humans.
ISSN:1368-8375
1879-0593
DOI:10.1016/S1368-8375(01)00126-9