Association Between Nonsteroidal Anti-Inflammatory Drug Use and the Incidence of Pancreatic Cancer

Laboratory studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) may inhibit pancreatic cancer, but epidemiologic data to support this finding are limited. We conducted a prospective study from 1992 through 1999 among 28 283 postmenopausal women who lived in Iowa to examine the associa...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 2002-08, Vol.94 (15), p.1168-1171
Main Authors: Anderson, Kristin E., Johnson, Trista W., Lazovich, DeAnn, Folsom, Aaron R.
Format: Article
Language:English
Subjects:
Aged
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Anticarcinogenic Agents - pharmacology
Aspirin
Aspirin - pharmacology
Biological and medical sciences
Cancer
Female
Gastroenterology. Liver. Pancreas. Abdomen
Health risk assessment
Humans
Incidence
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Middle Aged
Pancreas
Pancreatic cancer
Pancreatic Neoplasms - epidemiology
Pancreatic Neoplasms - prevention & control
Preventive medicine
Prospective Studies
Tumors
Women
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Summary:Laboratory studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) may inhibit pancreatic cancer, but epidemiologic data to support this finding are limited. We conducted a prospective study from 1992 through 1999 among 28 283 postmenopausal women who lived in Iowa to examine the association between the self-reported use of aspirin and other NSAIDs and the incidence of pancreatic cancer. Eighty incident cases of pancreatic cancer were identified during 7 years of follow-up. The multivariate-adjusted relative risk of pancreatic cancer associated with any current use of aspirin versus no use was 0.57 (95% confidence interval = 0.36 to 0.90). There was a trend of decreasing risk of pancreatic cancer incidence with increasing frequency of aspirin use per week (Ptrend = .005). Nonaspirin NSAID use was not associated with incident pancreatic cancer. These data indicate that aspirin might be chemopreventive for pancreatic cancer.
ISSN:0027-8874
1460-2105
1460-2105
DOI:10.1093/jnci/94.15.1168