Parallel Quorum Sensing Systems Converge to Regulate Virulence in Vibrio cholerae

The marine bacterium Vibrio harveyi possesses two quorum sensing systems (System 1 and System 2) that regulate bioluminescence. Although the Vibrio cholerae genome sequence reveals that a V. harveyi-like System 2 exists, it does not predict the existence of a V. harveyi-like System 1 or any obvious...

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Bibliographic Details
Published in:Cell 2002-08, Vol.110 (3), p.303-314
Main Authors: Miller, Melissa B., Skorupski, Karen, Lenz, Derrick H., Taylor, Ronald K., Bassler, Bonnie L.
Format: Article
Language:English
Subjects:
4-Butyrolactone - analogs & derivatives
4-Butyrolactone - genetics
Bacterial Proteins - genetics
Bacterial Proteins - isolation & purification
Cell Communication - genetics
DNA, Bacterial - genetics
Gene Expression Regulation, Bacterial - genetics
Luminescent Proteins - genetics
Luminescent Proteins - metabolism
Phosphoproteins - genetics
Phosphoproteins - metabolism
Repressor Proteins - genetics
Repressor Proteins - metabolism
Signal Transduction - genetics
Trans-Activators - genetics
Trans-Activators - metabolism
Vibrio cholerae - genetics
Vibrio cholerae - pathogenicity
Virulence - genetics
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Summary:The marine bacterium Vibrio harveyi possesses two quorum sensing systems (System 1 and System 2) that regulate bioluminescence. Although the Vibrio cholerae genome sequence reveals that a V. harveyi-like System 2 exists, it does not predict the existence of a V. harveyi-like System 1 or any obvious quorum sensing-controlled target genes. In this report we identify and characterize the genes encoding an additional V. cholerae autoinducer synthase and its cognate sensor. Analysis of double mutants indicates that a third as yet unidentified sensory circuit exists in V. cholerae. This quorum sensing apparatus is unusually complex, as it is composed of at least three parallel signaling channels. We show that in V. cholerae these communication systems converge to control virulence.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(02)00829-2