Are rhoptries in Apicomplexan parasites secretory granules or secretory lysosomal granules?

Summary The club‐shaped rhoptries in Apicomplexan parasites are one of the most unusual secretory organelles among the eukaryotes, containing unusual lipid and protein cargo that is specialized for intracellular parasitism. Rhoptries have traditionally been viewed strictly as regulated secretory gra...

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Bibliographic Details
Published in:Molecular microbiology 2004-06, Vol.52 (6), p.1531-1541
Main Authors: Ngô, Huân M., Yang, Mei, Joiner, Keith A.
Format: Article
Language:English
Subjects:
Animals
Apicomplexa - metabolism
Apicomplexa - ultrastructure
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Lysosomes - chemistry
Lysosomes - diagnostic imaging
Lysosomes - metabolism
Microbiology
Plasmodium
Plasmodium - metabolism
Plasmodium - ultrastructure
Secretory Vesicles - chemistry
Secretory Vesicles - metabolism
Secretory Vesicles - ultrastructure
Toxoplasma
Toxoplasma - metabolism
Toxoplasma - ultrastructure
Ultrasonography
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Summary:Summary The club‐shaped rhoptries in Apicomplexan parasites are one of the most unusual secretory organelles among the eukaryotes, containing unusual lipid and protein cargo that is specialized for intracellular parasitism. Rhoptries have traditionally been viewed strictly as regulated secretory granules. We discuss in this article recent data on the cargo, function and biogenesis of rhoptries in two parasitic model systems, Toxoplasma and Plasmodium. Current findings suggest that rhoptries receive products from both biosynthetic and endocytic pathways and, therefore, they are most analogous to secretory lysosomal granules found in mammalian cells.
ISSN:0950-382X
1365-2958
DOI:10.1111/j.1365-2958.2004.04056.x