Persistence of Human Papillomavirus Infection in HIV-Infected and -Uninfected Adolescent Girls: Risk Factors and Differences, by Phylogenetic Type

Background. High rates of persistence of human papillomavirus (HPV) infection have been reported for adult women with human immunodeficiency virus (HIV) infection. Although most women are first infected with HPV during adolescence, persistence of specific HPV types has not been carefully examined am...

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Bibliographic Details
Published in:The Journal of infectious diseases 2004-07, Vol.190 (1), p.37-45
Main Authors: Moscicki, Anna-Barbara, Ellenberg, Jonas H., Farhat, Sepideh, Xu, Jiahong
Format: Article
Language:English
Subjects:
Adolescent
Adolescents
AIDS
AIDS-Related Opportunistic Infections - complications
AIDS-Related Opportunistic Infections - epidemiology
AIDS-Related Opportunistic Infections - virology
Biological and medical sciences
Cohort Studies
Cytokines
DNA, Viral - blood
Female
Fundamental and applied biological sciences. Psychology
HIV
HIV infections
HIV Infections - complications
HIV Infections - epidemiology
HIV Seronegativity
Human immunodeficiency virus
Human papillomavirus
Human viral diseases
Humans
Infections
Infectious diseases
Marijuana use
Medical sciences
Microbiology
Miscellaneous
Papillomaviridae - classification
Papillomaviridae - genetics
Papillomaviridae - isolation & purification
Papillomavirus infections
Papillomavirus Infections - complications
Papillomavirus Infections - epidemiology
Papillomavirus Infections - virology
Phylogenetics
Phylogeny
Prevalence
Prospective Studies
Risk Factors
Survival Analysis
T lymphocytes
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Virology
Viruses
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Summary:Background. High rates of persistence of human papillomavirus (HPV) infection have been reported for adult women with human immunodeficiency virus (HIV) infection. Although most women are first infected with HPV during adolescence, persistence of specific HPV types has not been carefully examined among HIV-infected adolescents. The objective of this study was to examine the rates of and risk factors for persistence of HPV types among HIV-infected and -uninfected adolescent girls. Methods. This is a prospective cohort study of female adolescents, aged 13–18 years, participating in the Reaching for Excellence in Adolescent Care and Health project, a national study of HIV-infected and -uninfected adolescents. The main outcome measured was type-specific loss of initial HPV DNA detected. Loss of HPV DNA was defined for the following categories of HPV DNA types: low risk, which included types 6, 11, 42, 44, 54, 40, 13, 32, 62, 72, 2, 57, and 55; and high risk, which included types 16-like (16, 31, 33, 35, 52, 58, and 67), 18-like (18, 39, 45, 59, 68, 70, 26, 69, and 51), and 56-like (56, 53, and 66). Results. Prevalent or incident HPV infection was detected in 334 girls. When type-specific loss of HPV was examined, HIV-uninfected girls had a shorter mean time to loss of initial infection than did HIV-infected girls (403 days vs. 689 days, respectively; P
ISSN:0022-1899
1537-6613
DOI:10.1086/421467