Peters’ anomaly with bilateral perisylvian polymicrogyria and abdominal calcification

ABSTRACT  We report a neonatal case of Peters’ anomaly with bilateral perisylvian polymicrogyria and abdominal calcification. The male infant was born after a normal labor. Bilateral central corneal opacities with iridocorneal strands indicated Peters’ anomaly. The X‐ray and abdominal computed tomog...

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Bibliographic Details
Published in:Congenital anomalies 2004-06, Vol.44 (2), p.99-102
Main Authors: Morimoto, Mayumi, Takano, Tomoyuki, Sakaue, Yuko, Sawai, Chihiro, Aotani, Hirofumi, Koshida, Shigeki, Takeuchi, Yoshihiro
Format: Article
Language:English
Subjects:
Abdomen
abdominal calcification
Abnormalities, Multiple
bilateral perisylvian polymicrogyria
Brain - abnormalities
Calcinosis - congenital
Corneal Opacity - congenital
Humans
Infant, Newborn
Iris Diseases - congenital
Male
Peters’ anomaly
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Summary:ABSTRACT  We report a neonatal case of Peters’ anomaly with bilateral perisylvian polymicrogyria and abdominal calcification. The male infant was born after a normal labor. Bilateral central corneal opacities with iridocorneal strands indicated Peters’ anomaly. The X‐ray and abdominal computed tomography demonstrated multiple calcifications beneath the diaphragma around the liver and the spleen. TORCH serology was negative. Intracranial calcification was not detected. Brain magnetic resonance imaging demonstrated bilateral perisylvian polymicrogyria. Abdominal calcification was suspected to be related to vascular disruption. Bilateral perisylvian polymicrogyria has been thought to result from ischemic events such as intrauterine hypotension or vascular occlusions. Based on these considerations, we conclude that a vascular disruption sequence may an important pathogenetic mechanism of Peters’ anomaly.
ISSN:0914-3505
1741-4520
DOI:10.1111/j.1741-4520.2004.00016.x