Diabetes and haemodynamic reactions to acute coronary occlusion

Background: The risk of early sudden death before hospital admission is higher in diabetic than non-diabetic men with acute myocardial infarction and autonomic nervous activity may modify the clinical outcome of abrupt coronary occlusion. Since diabetes mellitus may interfere with autonomic and myoc...

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Bibliographic Details
Published in:International journal of cardiology 2004-06, Vol.95 (2), p.237-244
Main Authors: Airaksinen, K.E.Juhani, Koivikko, Minna L., Niemelä, Matti J., Tahvanainen, Kari U.O., Linnaluoto, Markku, Huikuri, Heikki V.
Format: Article
Language:English
Subjects:
Autonomic Nervous System - physiopathology
Autonomic Nervous System Diseases - etiology
Autonomic Nervous System Diseases - physiopathology
Autonomic neuropathy
Baroreflex
Baroreflexes
Biological and medical sciences
Blood pressure
Cardiology. Vascular system
Case-Control Studies
Coronary Disease - complications
Coronary Disease - physiopathology
Coronary heart disease
Diabetes Complications
Female
Heart
Heart rate
Hemodynamics
Humans
Hypotension - etiology
Hypotension - physiopathology
Logistic Models
Male
Medical sciences
Middle Aged
Ventricular Premature Complexes - etiology
Ventricular Premature Complexes - physiopathology
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Summary:Background: The risk of early sudden death before hospital admission is higher in diabetic than non-diabetic men with acute myocardial infarction and autonomic nervous activity may modify the clinical outcome of abrupt coronary occlusion. Since diabetes mellitus may interfere with autonomic and myocardial function, we decided to study whether diabetes alters autonomic and haemodynamic responses to acute coronary occlusion. Methods: We analyzed the changes in heart rate, heart rate variability and blood pressure, and the occurrence of ventricular ectopy during a 2-min coronary occlusion in 238 non-diabetic and 32 diabetic patients referred for single vessel coronary angioplasty. The ranges of non-specific responses were determined by analyzing a control group of 19 patients with no ischaemia during a 2-min balloon inflation in a totally occluded coronary artery. Results: Diabetic patients were more often ( p
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2003.06.004