Cell sorting in animal development: signalling and adhesive mechanisms in the formation of tissue boundaries

The organisation of the animal body into distinct tissues requires adhesive mechanisms that promote and maintain the physical segregation, the sorting, of different cell populations. Signals that control differential cell affinities across tissue boundaries have been identified, including Hedgehog,...

Full description

Saved in:
Bibliographic Details
Published in:Current Opinion in Genetics & Development 2002-10, Vol.12 (5), p.572-582
Main Authors: Tepass, Ulrich, Godt, Dorothea, Winklbauer, Rudolf
Format: Article
Language:English
Subjects:
Animals
cadherin
Cadherins
Cell Adhesion
Cell Communication
Cell Differentiation - physiology
Cell Lineage
Cell Movement
cell sorting
compartment
Drosophila melanogaster - embryology
Drosophila melanogaster - growth & development
Drosophila melanogaster - physiology
Drosophila Proteins
EGF receptor
Eph receptor
ephrin
Ephrins - physiology
ErbB Receptors - metabolism
hedgehog
Hedgehog Proteins - physiology
Humans
Membrane Proteins - metabolism
Morphogenesis - physiology
Notch
Receptor Protein-Tyrosine Kinases - metabolism
Receptors, Notch
Signal Transduction - physiology
tissue boundary
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The organisation of the animal body into distinct tissues requires adhesive mechanisms that promote and maintain the physical segregation, the sorting, of different cell populations. Signals that control differential cell affinities across tissue boundaries have been identified, including Hedgehog, Notch, and EGF receptor signalling. Further, several examples demonstrate that cell sorting in vivo can be driven by Eph/ephrin signalling and by the differential expression of cadherins that modulate cell adhesion and motility. Cell sorting and the formation of tissue boundaries are major morphogenetic processes in animal development. Recent progress elucidates signalling mechanisms that control boundary formation and adhesive cell interactions mediated by cadherins that facilitate cell sorting.
ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(02)00342-8