Immunoglobulin G antibody avidity assay for serodiagnosis of hepatitis C virus infection

It has been reported that the avidity of specific IgG antibody is lower in primary viral infection than in chronic viral infection. However, few studies have been reported on the IgG avidity in hepatitis C virus (HCV) infection. In the present study, 36 patients with antibody to HCV (anti‐HCV) were...

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Bibliographic Details
Published in:Journal of medical virology 2002-10, Vol.68 (2), p.229-233
Main Authors: Kanno, Atsushi, Kazuyama, Yukumasa
Format: Article
Language:English
Subjects:
Acute Disease
Adult
anti-HCV
Antibody Affinity
avidity
Bacterial diseases
Bacteriology
Biological and medical sciences
Experimental bacterial diseases and models
Female
Fundamental and applied biological sciences. Psychology
Hepacivirus - immunology
Hepacivirus - isolation & purification
Hepatitis C - diagnosis
Hepatitis C - immunology
Hepatitis C - virology
Hepatitis C Antibodies - blood
Hepatitis C, Chronic - diagnosis
Hepatitis C, Chronic - immunology
Hepatitis C, Chronic - virology
Humans
IgG
Immunoglobulin G - blood
Infectious diseases
Male
Medical sciences
Microbiology
Middle Aged
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
RNA, Viral - blood
Serologic Tests
Time Factors
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Summary:It has been reported that the avidity of specific IgG antibody is lower in primary viral infection than in chronic viral infection. However, few studies have been reported on the IgG avidity in hepatitis C virus (HCV) infection. In the present study, 36 patients with antibody to HCV (anti‐HCV) were examined for IgG avidity by an enzyme immunoassay with or without urea elution. The avidity index was significantly low in patients with primary HCV infection (7.7 ± 6.8%, mean ± SD), compared with patients with chronic HCV infection (77.0 ± 21.8%) and individuals with past HCV infection (44.5 ± 12.6%). Temporal changes of IgG avidity were examined in six patients with primary HCV infection. The avidity index was low in the acute phase of the infection and then increased with time. These results suggest that the avidity assay for IgG anti‐HCV is a useful method for distinguishing primary HCV infection from chronic or past HCV infection. J. Med. Virol. 68:229–233, 2002. © 2002 Wiley‐Liss, Inc.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.10186