Diet and cancer: assessing the risk

Globally, colorectal cancer (CRC) is a leading cause of mortality from malignant disease. Case–control and cohort studies provide strong support for a role of diet in the aetiology of CRC. However to establish causal relationships and to identify more precisely the dietary components involved, inter...

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Bibliographic Details
Published in:British journal of nutrition 2002-09, Vol.88 (S1), p.s73-s87
Main Authors: Gill, C. I. R., Rowland, I. R.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomarkers
Biomarkers, Tumor - analysis
Cancer research
Cell Transformation, Neoplastic
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - etiology
Diet
Diet - adverse effects
Epidemiology
Etiology
Fatty acids
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Kinases
Medical research
Medical sciences
Mortality
Nutrition research
Other diseases. Semiology
Risk Assessment
Risk Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
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Summary:Globally, colorectal cancer (CRC) is a leading cause of mortality from malignant disease. Case–control and cohort studies provide strong support for a role of diet in the aetiology of CRC. However to establish causal relationships and to identify more precisely the dietary components involved, intervention studies in human subjects are required. Cancer is an impractical endpoint in terms of numbers, cost, study duration and ethical considerations. Consequently, intermediate biomarkers of the disease are required. This review aims to provide an overview of the intermediate endpoints available for the study of CRC, particularly non-invasive faecal biomarkers. Examples of their use in dietary intervention studies are given.
ISSN:0007-1145
1475-2662
DOI:10.1079/BJN2002632