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Plasma homocysteine levels and atherosclerosis in Japan: Epidemiological study by use of carotid ultrasonography
We examined whether hyperhomocysteinemia is an independent risk factor for increased carotid artery intimal-medial wall thickness (IMT) in a large, randomly selected community in Japan where the dietary habit is different and the incidence of coronary artery disease is lower compared with those of w...
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| Published in: | Stroke (1970) 2002-09, Vol.33 (9), p.2177-2181 |
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| Main Authors: | , , , , , |
| Format: | Article |
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| container_end_page | 2181 |
| container_issue | 9 |
| container_start_page | 2177 |
| container_title | Stroke (1970) |
| container_volume | 33 |
| creator | ADACHI, Hisashi HIRAI, Yuji FUJIURA, Yoshihisa MATSUOKA, Hidehiro SATOH, Akira IMAIZUMI, Tsutomu |
| description | We examined whether hyperhomocysteinemia is an independent risk factor for increased carotid artery intimal-medial wall thickness (IMT) in a large, randomly selected community in Japan where the dietary habit is different and the incidence of coronary artery disease is lower compared with those of western countries.
In 1111 cases (452 men, 659 women) aged 63+/-10 years old (range, 40 to 94 years) recruited from a population-based survey performed in 1999, we measured fasting plasma total homocysteine levels and performed bilateral carotid B-mode ultrasound. The participants underwent measurements of other blood chemistries (total cholesterol, HDL cholesterol, glycosylated hemoglobin A(1c), and creatinine).
For the total population, the mean total homocysteine level was 10.9 micro mol/L. Total homocysteine levels were higher in men than in women and increased with aging. With multiple linear regression analysis after adjustments for age and sex, the most powerful determinant of total homocysteine levels was serum creatinine (P |
| doi_str_mv | 10.1161/01.STR.0000026861.18199.89 |
| format | article |
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In 1111 cases (452 men, 659 women) aged 63+/-10 years old (range, 40 to 94 years) recruited from a population-based survey performed in 1999, we measured fasting plasma total homocysteine levels and performed bilateral carotid B-mode ultrasound. The participants underwent measurements of other blood chemistries (total cholesterol, HDL cholesterol, glycosylated hemoglobin A(1c), and creatinine).
For the total population, the mean total homocysteine level was 10.9 micro mol/L. Total homocysteine levels were higher in men than in women and increased with aging. With multiple linear regression analysis after adjustments for age and sex, the most powerful determinant of total homocysteine levels was serum creatinine (P<0.001). With multiple stepwise regression analysis after adjustments for age, sex, and other confounding factors, total homocysteine was significantly (P<0.05) related to IMT. Furthermore, when mean values of IMT adjusted for age, sex, and other related factors were analyzed across total homocysteine quartiles, IMT (P<0.05) showed a significant trend as total homocysteine level increased.
Plasma total homocysteine levels in Japan are similar to those reported in western countries. Mild hyperhomocysteinemia is an independent risk factor for increased carotid artery wall thickness in Japan as well.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.STR.0000026861.18199.89</identifier><identifier>PMID: 12215583</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Age Distribution ; Aged ; Aged, 80 and over ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Carotid Arteries - diagnostic imaging ; Carotid Artery Diseases - blood ; Carotid Artery Diseases - diagnostic imaging ; Carotid Artery Diseases - epidemiology ; Creatinine - blood ; Female ; Homocysteine - blood ; Humans ; Japan - epidemiology ; Male ; Medical sciences ; Middle Aged ; Predictive Value of Tests ; Regression Analysis ; Risk Factors ; Sex Distribution ; Tunica Intima - diagnostic imaging ; Tunica Media - diagnostic imaging ; Ultrasonography</subject><ispartof>Stroke (1970), 2002-09, Vol.33 (9), p.2177-2181</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Sep 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c351t-b976f3ef65e450896b3fd4fb704bfaacc6f67f4d769703369d8b7f4aa47f1bbb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13920126$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12215583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ADACHI, Hisashi</creatorcontrib><creatorcontrib>HIRAI, Yuji</creatorcontrib><creatorcontrib>FUJIURA, Yoshihisa</creatorcontrib><creatorcontrib>MATSUOKA, Hidehiro</creatorcontrib><creatorcontrib>SATOH, Akira</creatorcontrib><creatorcontrib>IMAIZUMI, Tsutomu</creatorcontrib><title>Plasma homocysteine levels and atherosclerosis in Japan: Epidemiological study by use of carotid ultrasonography</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>We examined whether hyperhomocysteinemia is an independent risk factor for increased carotid artery intimal-medial wall thickness (IMT) in a large, randomly selected community in Japan where the dietary habit is different and the incidence of coronary artery disease is lower compared with those of western countries.
In 1111 cases (452 men, 659 women) aged 63+/-10 years old (range, 40 to 94 years) recruited from a population-based survey performed in 1999, we measured fasting plasma total homocysteine levels and performed bilateral carotid B-mode ultrasound. The participants underwent measurements of other blood chemistries (total cholesterol, HDL cholesterol, glycosylated hemoglobin A(1c), and creatinine).
For the total population, the mean total homocysteine level was 10.9 micro mol/L. Total homocysteine levels were higher in men than in women and increased with aging. With multiple linear regression analysis after adjustments for age and sex, the most powerful determinant of total homocysteine levels was serum creatinine (P<0.001). With multiple stepwise regression analysis after adjustments for age, sex, and other confounding factors, total homocysteine was significantly (P<0.05) related to IMT. Furthermore, when mean values of IMT adjusted for age, sex, and other related factors were analyzed across total homocysteine quartiles, IMT (P<0.05) showed a significant trend as total homocysteine level increased.
Plasma total homocysteine levels in Japan are similar to those reported in western countries. Mild hyperhomocysteinemia is an independent risk factor for increased carotid artery wall thickness in Japan as well.</description><subject>Adult</subject><subject>Age Distribution</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Artery Diseases - blood</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Carotid Artery Diseases - epidemiology</subject><subject>Creatinine - blood</subject><subject>Female</subject><subject>Homocysteine - blood</subject><subject>Humans</subject><subject>Japan - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Tunica Intima - diagnostic imaging</subject><subject>Tunica Media - diagnostic imaging</subject><subject>Ultrasonography</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNpdkd1r1jAUh4Mo7nX6L0gY6F1rPtp87E7GdJPBRLfrkKTJ3oy0qUk76H-_dnvhBc9FDoHn5ITfA8AZRjXGDH9DuP5796dGWxEmGK6xwFLWQr4BO9ySpmoYEW_BDiEqK9JIeQI-lPK44VS078EJJgS3raA7MP6OuvQa7lOf7FImFwYHo3tysUA9dFBPe5dTsXE7Q4FhgL_0qIdzeDmGzvUhxfQQrI6wTHO3QLPAuTiYPLQ6pyl0cI5T1iUN6SHrcb98BO-8jsV9OvRTcP_j8u7iqrq5_Xl98f2msrTFU2UkZ546z1rXtEhIZqjvGm84aozX2lrmGfdNx5nkiFImO2HWu9YN99gYQ0_B19d3x5z-za5Mqg_Fuhj14NJcFCeIccL5Cp79Bz6mOQ_r3xSWXFCCmVyh81fIrjGU7Lwac-h1XhRGapOiEFarFHWUol6kKLENfz5smE3vuuPowcIKfDkAuqxR-qwHG8qRo5IgTBh9Buixl9U</recordid><startdate>20020901</startdate><enddate>20020901</enddate><creator>ADACHI, Hisashi</creator><creator>HIRAI, Yuji</creator><creator>FUJIURA, Yoshihisa</creator><creator>MATSUOKA, Hidehiro</creator><creator>SATOH, Akira</creator><creator>IMAIZUMI, Tsutomu</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20020901</creationdate><title>Plasma homocysteine levels and atherosclerosis in Japan: Epidemiological study by use of carotid ultrasonography</title><author>ADACHI, Hisashi ; HIRAI, Yuji ; FUJIURA, Yoshihisa ; MATSUOKA, Hidehiro ; SATOH, Akira ; IMAIZUMI, Tsutomu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-b976f3ef65e450896b3fd4fb704bfaacc6f67f4d769703369d8b7f4aa47f1bbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Age Distribution</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Carotid Artery Diseases - blood</topic><topic>Carotid Artery Diseases - diagnostic imaging</topic><topic>Carotid Artery Diseases - epidemiology</topic><topic>Creatinine - blood</topic><topic>Female</topic><topic>Homocysteine - blood</topic><topic>Humans</topic><topic>Japan - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Tunica Intima - diagnostic imaging</topic><topic>Tunica Media - diagnostic imaging</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ADACHI, Hisashi</creatorcontrib><creatorcontrib>HIRAI, Yuji</creatorcontrib><creatorcontrib>FUJIURA, Yoshihisa</creatorcontrib><creatorcontrib>MATSUOKA, Hidehiro</creatorcontrib><creatorcontrib>SATOH, Akira</creatorcontrib><creatorcontrib>IMAIZUMI, Tsutomu</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ADACHI, Hisashi</au><au>HIRAI, Yuji</au><au>FUJIURA, Yoshihisa</au><au>MATSUOKA, Hidehiro</au><au>SATOH, Akira</au><au>IMAIZUMI, Tsutomu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma homocysteine levels and atherosclerosis in Japan: Epidemiological study by use of carotid ultrasonography</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2002-09-01</date><risdate>2002</risdate><volume>33</volume><issue>9</issue><spage>2177</spage><epage>2181</epage><pages>2177-2181</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>We examined whether hyperhomocysteinemia is an independent risk factor for increased carotid artery intimal-medial wall thickness (IMT) in a large, randomly selected community in Japan where the dietary habit is different and the incidence of coronary artery disease is lower compared with those of western countries.
In 1111 cases (452 men, 659 women) aged 63+/-10 years old (range, 40 to 94 years) recruited from a population-based survey performed in 1999, we measured fasting plasma total homocysteine levels and performed bilateral carotid B-mode ultrasound. The participants underwent measurements of other blood chemistries (total cholesterol, HDL cholesterol, glycosylated hemoglobin A(1c), and creatinine).
For the total population, the mean total homocysteine level was 10.9 micro mol/L. Total homocysteine levels were higher in men than in women and increased with aging. With multiple linear regression analysis after adjustments for age and sex, the most powerful determinant of total homocysteine levels was serum creatinine (P<0.001). With multiple stepwise regression analysis after adjustments for age, sex, and other confounding factors, total homocysteine was significantly (P<0.05) related to IMT. Furthermore, when mean values of IMT adjusted for age, sex, and other related factors were analyzed across total homocysteine quartiles, IMT (P<0.05) showed a significant trend as total homocysteine level increased.
Plasma total homocysteine levels in Japan are similar to those reported in western countries. Mild hyperhomocysteinemia is an independent risk factor for increased carotid artery wall thickness in Japan as well.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12215583</pmid><doi>10.1161/01.STR.0000026861.18199.89</doi><tpages>5</tpages></addata></record> |
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| ispartof | Stroke (1970), 2002-09, Vol.33 (9), p.2177-2181 |
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| language | eng |
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| source | Alma/SFX Local Collection |
| subjects | Adult Age Distribution Aged Aged, 80 and over Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Carotid Arteries - diagnostic imaging Carotid Artery Diseases - blood Carotid Artery Diseases - diagnostic imaging Carotid Artery Diseases - epidemiology Creatinine - blood Female Homocysteine - blood Humans Japan - epidemiology Male Medical sciences Middle Aged Predictive Value of Tests Regression Analysis Risk Factors Sex Distribution Tunica Intima - diagnostic imaging Tunica Media - diagnostic imaging Ultrasonography |
| title | Plasma homocysteine levels and atherosclerosis in Japan: Epidemiological study by use of carotid ultrasonography |
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