Lymphocyte subsets and assessment of cancer risk in renal transplant recipients

Renal transplant recipients have a well‐recognized increased risk of de novo neoplasia. In this study, we investigated whether lymphocyte subset count could predict the risk of developing noncutaneous neoplasia (NCSC) in renal transplant recipients (RTR). Between January 1995 and December 1995, lymp...

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Published in:Transplant international 2002-09, Vol.15 (8), p.393-396
Main Authors: Ducloux, Didier, Carron, Pierre‐Louis, Motte, Gerard, Ab, Abdelfatah, Rebibou, Jean‐Michel, Bresson‐Vautrin, Catherine, Tiberghien, Pierre, Saint‐Hillier, Yves, Chalopin, Jean‐Marc
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Language:English
Subjects:
Adult
Aged
Antigens, CD19 - analysis
Biological and medical sciences
Cancer
Carcinogenesis, carcinogens and anticarcinogens
CD4 Lymphocyte Count
Female
General aspects
Humans
Immunosuppression
Kidney Transplantation - adverse effects
Kidney Transplantation - immunology
Lymphocyte subsets
Male
Medical sciences
Middle Aged
Neoplasms - etiology
Renal transplantation
Risk
Tumors
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container_issue 8
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container_title Transplant international
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creator Ducloux, Didier
Carron, Pierre‐Louis
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Ab, Abdelfatah
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Saint‐Hillier, Yves
Chalopin, Jean‐Marc
description Renal transplant recipients have a well‐recognized increased risk of de novo neoplasia. In this study, we investigated whether lymphocyte subset count could predict the risk of developing noncutaneous neoplasia (NCSC) in renal transplant recipients (RTR). Between January 1995 and December 1995, lymphocyte subsets (CD4, CD8, CD19) were measured in 281 RTR. This population was studied until November 1999 for the development of NCSC. The mean follow‐up was 42±9 months. Neoplasm was diagnosed in 22 patients (7.9%). Patients who developed a cancer were significantly older (53.8±6 years vs 38±16 years, P
doi_str_mv 10.1111/j.1432-2277.2002.tb00187.x
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In this study, we investigated whether lymphocyte subset count could predict the risk of developing noncutaneous neoplasia (NCSC) in renal transplant recipients (RTR). Between January 1995 and December 1995, lymphocyte subsets (CD4, CD8, CD19) were measured in 281 RTR. This population was studied until November 1999 for the development of NCSC. The mean follow‐up was 42±9 months. Neoplasm was diagnosed in 22 patients (7.9%). Patients who developed a cancer were significantly older (53.8±6 years vs 38±16 years, P&lt;0.0001), had lower CD4 (234±126/mm3 vs 543±214/mm3, P&lt;0.005) and CD19 (19±9/mm3 vs 51±22/mm3, P&lt;0.0001) levels, and more frequently had past histories of skin cancer (24% vs 4%, P&lt;0.01). Cox regression revealed that high CD4 levels (RR 0.73, 95% CI 0.62–0.89 for each 100/mm3 increase in CD4 cell count) were associated with decreased risk of NCSC, whereas age (RR 2.49, 95% CI 1.12–5.92 for each 10‐year increase in age) was predictive of the subsequent development of NCSC. 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Cox regression revealed that high CD4 levels (RR 0.73, 95% CI 0.62–0.89 for each 100/mm3 increase in CD4 cell count) were associated with decreased risk of NCSC, whereas age (RR 2.49, 95% CI 1.12–5.92 for each 10‐year increase in age) was predictive of the subsequent development of NCSC. 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Cox regression revealed that high CD4 levels (RR 0.73, 95% CI 0.62–0.89 for each 100/mm3 increase in CD4 cell count) were associated with decreased risk of NCSC, whereas age (RR 2.49, 95% CI 1.12–5.92 for each 10‐year increase in age) was predictive of the subsequent development of NCSC. To conclude, CD4 cell depletion is associated with the development of solid cancers and lymphoma in RTR.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>12221457</pmid><doi>10.1111/j.1432-2277.2002.tb00187.x</doi><tpages>4</tpages></addata></record>
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ispartof Transplant international, 2002-09, Vol.15 (8), p.393-396
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1432-2277
language eng
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source Alma/SFX Local Collection
subjects Adult
Aged
Antigens, CD19 - analysis
Biological and medical sciences
Cancer
Carcinogenesis, carcinogens and anticarcinogens
CD4 Lymphocyte Count
Female
General aspects
Humans
Immunosuppression
Kidney Transplantation - adverse effects
Kidney Transplantation - immunology
Lymphocyte subsets
Male
Medical sciences
Middle Aged
Neoplasms - etiology
Renal transplantation
Risk
Tumors
title Lymphocyte subsets and assessment of cancer risk in renal transplant recipients
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