Detection of Antimicrobial Resistance and Extended-Spectrum β-Lactamase Production in Klebsiella Pneumoniae Strains from Infected Neonates

The present study was designed to determine the antimicrobial resistance and extended-spectrum β-lactamase (ESBL) activities of Klebsiella pneumoniae strains isolated from the neonatal intensive care unit of Atatürk University Hospital, Erzurum, Turkey. Antibiotic susceptibility of 40 isolates was d...

Full description

Saved in:
Bibliographic Details
Published in:Journal of international medical research 2002-07, Vol.30 (4), p.445-448
Main Authors: Aktas, E, Yigit, N, Yazgi, H, Ayyildiz, A
Format: Article
Language:English
Subjects:
Ampicillin - pharmacology
Ampicillin - therapeutic use
Ampicillin Resistance
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
beta-Lactam Resistance
beta-Lactamases - biosynthesis
Cephalosporin Resistance
Cephalosporins - pharmacology
Cephalosporins - therapeutic use
Humans
Infant, Newborn
Klebsiella Infections - drug therapy
Klebsiella Infections - microbiology
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - enzymology
Microbial Sensitivity Tests
Thienamycins - pharmacology
Thienamycins - therapeutic use
Turkey
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The present study was designed to determine the antimicrobial resistance and extended-spectrum β-lactamase (ESBL) activities of Klebsiella pneumoniae strains isolated from the neonatal intensive care unit of Atatürk University Hospital, Erzurum, Turkey. Antibiotic susceptibility of 40 isolates was detected by the standard disk diffusion method according to the National Committee for Clinical Laboratory Standards Guidelines. The double-disk synergy method was used to determine ESBL activity, which is associated with resistance to β-lactam antibiotics. Twenty-four (60%) of 40 K. pneumoniae strains were found to produce ESBL. Of the antibiotics tested, meropenem was found to be the most effective (100%), and ampicillin the least effective (0%). With the increasing incidence of antimicrobial resistance, which poses a clinically significant risk to vulnerable patients, it is important that clinical microbiology laboratories have accurate and timely information concerning the strains of bacteria present to enable them to predict which antibiotics are likely to be effective in treating the infections they may cause.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323000203000414