Causes for massive bacterial colonization on mucosal membranes during infectious mononucleosis: implications for acute otitis media

Objective: A common complication of virus-induced upper respiratory tract infections is acute otitis media caused by bacterial pathogens. Simultaneously, increased bacterial colonization in the nasopharynx occurs. Our intention in this study was to identify the causes of this increased colonization...

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Bibliographic Details
Published in:International journal of pediatric otorhinolaryngology 2002-09, Vol.65 (3), p.233-240
Main Authors: Stenfors, Lars-Eric, Bye, Helga-Marie, Räisänen, Simo
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Bacterial colonization
Biological and medical sciences
Case-Control Studies
Child
Data Interpretation, Statistical
Ear infection
Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology
Epithelial Cells - microbiology
Epstein–Barr virus
Female
Herpesvirus 4, Human
Human viral diseases
Humans
Immunity, Mucosal
Immunoglobulin A, Secretory - analysis
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Infectious diseases
Infectious Mononucleosis - immunology
Infectious Mononucleosis - virology
Lactoferrin - analysis
Male
Medical sciences
Microscopy, Electron
Miscellaneous
Mucosal immunity
Muramidase - analysis
Nasal Mucosa - immunology
Nasal Mucosa - microbiology
Nasopharynx - microbiology
Non tumoral diseases
Otitis media
Otitis Media - immunology
Otitis Media - microbiology
Otorhinolaryngology. Stomatology
Pharyngitis - microbiology
Viral diseases
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Summary:Objective: A common complication of virus-induced upper respiratory tract infections is acute otitis media caused by bacterial pathogens. Simultaneously, increased bacterial colonization in the nasopharynx occurs. Our intention in this study was to identify the causes of this increased colonization of bacteria by evaluating their coating with the antibacterial substances lysozyme, lactoferrin and immunoglobulins IgG, S-IgA and IgM and their ability to penetrate epithelial cells during infectious mononucleosis (IM) caused by Epstein–Barr virus. Methods: Cellular samples were collected from the oropharynx of 21 patients (16 males, five females; age range 10–21 years) with current IM. An immunocytochemical assay using gold-labelled antiserum to human lysozyme, lactoferrin, IgG, S-IgA and IgM followed by gold particle and epithelial cell tracing in the transmission electron microscope. Results: A significant reduction in bacterial coating with IgG ( P
ISSN:0165-5876
1872-8464
DOI:10.1016/S0165-5876(02)00180-5