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Metal versus plastic spacers: an in vitro and in vivo comparison
This study compared the metal Nebuchamber® with the polycarbonate Volumatic® spacer in vivo as well as in vitro. Seventeen asthmatic patients were evaluated in a crossover placebo-controlled double-blind study. Bronchodilation, heart rate and serum potassium levels were measured at baseline and 15 m...
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| Published in: | International journal of pharmaceutics 2002-10, Vol.245 (1), p.93-98 |
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| Main Authors: | , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c391t-25ca46597d6b244d1f6fa416c0ce172d149642eaefe1ddb651d890e47f881fe13 |
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| cites | cdi_FETCH-LOGICAL-c391t-25ca46597d6b244d1f6fa416c0ce172d149642eaefe1ddb651d890e47f881fe13 |
| container_end_page | 98 |
| container_issue | 1 |
| container_start_page | 93 |
| container_title | International journal of pharmaceutics |
| container_volume | 245 |
| creator | Janssen, R Weda, M Ekkelenkamp, M.B Lammers, J-W.J Zanen, P |
| description | This study compared the metal Nebuchamber® with the polycarbonate Volumatic® spacer in vivo as well as in vitro. Seventeen asthmatic patients were evaluated in a crossover placebo-controlled double-blind study. Bronchodilation, heart rate and serum potassium levels were measured at baseline and 15 min after administration of salbutamol. Cumulative dose-response curves (200, 400, 800 and 1600 μg) were constructed. The Andersen Cascade Impactor was used to compare the aerodynamic particle size distribution. The FEV
1 measurements showed highly significant differences between placebo and the two active preparations (
P0.05). In conclusion, there are no significant differences between the Volumatic® and Nebuchamber® either in vivo or in vitro. |
| doi_str_mv | 10.1016/S0378-5173(02)00330-7 |
| format | article |
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1 measurements showed highly significant differences between placebo and the two active preparations (
P<0.001), but not between the two active preparations (
P=0.433). The serum potassium levels also showed highly significant differences between placebo and the two active preparations (
P=0.009), but not between the two active preparations (
P=0.532). Only 1600 μg salbutamol dose raised the heart rate significantly, but the difference between the two active preparations was not significant. The in vitro deposition study revealed no significant differences in the delivered dose or in the fine particle dose (
P>0.05). In conclusion, there are no significant differences between the Volumatic® and Nebuchamber® either in vivo or in vitro.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/S0378-5173(02)00330-7</identifier><identifier>PMID: 12270246</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Administration, Inhalation ; Adult ; Albuterol - administration & dosage ; Albuterol - therapeutic use ; Asthma - drug therapy ; Biological and medical sciences ; Bronchodilation ; Bronchodilator Agents - administration & dosage ; Bronchodilator Agents - therapeutic use ; Cross-Over Studies ; Dose-Response Relationship, Drug ; Double-Blind Method ; Female ; General pharmacology ; Humans ; In vitro ; Inhalation Spacers ; Male ; Medical sciences ; Metals ; Middle Aged ; Nebuchamber ; Particle Size ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Plastics ; Respiratory system ; Salbutamol ; Volumatic</subject><ispartof>International journal of pharmaceutics, 2002-10, Vol.245 (1), p.93-98</ispartof><rights>2002 Elsevier Science B.V.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c391t-25ca46597d6b244d1f6fa416c0ce172d149642eaefe1ddb651d890e47f881fe13</citedby><cites>FETCH-LOGICAL-c391t-25ca46597d6b244d1f6fa416c0ce172d149642eaefe1ddb651d890e47f881fe13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13919275$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12270246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Janssen, R</creatorcontrib><creatorcontrib>Weda, M</creatorcontrib><creatorcontrib>Ekkelenkamp, M.B</creatorcontrib><creatorcontrib>Lammers, J-W.J</creatorcontrib><creatorcontrib>Zanen, P</creatorcontrib><title>Metal versus plastic spacers: an in vitro and in vivo comparison</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>This study compared the metal Nebuchamber® with the polycarbonate Volumatic® spacer in vivo as well as in vitro. Seventeen asthmatic patients were evaluated in a crossover placebo-controlled double-blind study. Bronchodilation, heart rate and serum potassium levels were measured at baseline and 15 min after administration of salbutamol. Cumulative dose-response curves (200, 400, 800 and 1600 μg) were constructed. The Andersen Cascade Impactor was used to compare the aerodynamic particle size distribution. The FEV
1 measurements showed highly significant differences between placebo and the two active preparations (
P<0.001), but not between the two active preparations (
P=0.433). The serum potassium levels also showed highly significant differences between placebo and the two active preparations (
P=0.009), but not between the two active preparations (
P=0.532). Only 1600 μg salbutamol dose raised the heart rate significantly, but the difference between the two active preparations was not significant. The in vitro deposition study revealed no significant differences in the delivered dose or in the fine particle dose (
P>0.05). In conclusion, there are no significant differences between the Volumatic® and Nebuchamber® either in vivo or in vitro.</description><subject>Administration, Inhalation</subject><subject>Adult</subject><subject>Albuterol - administration & dosage</subject><subject>Albuterol - therapeutic use</subject><subject>Asthma - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Bronchodilation</subject><subject>Bronchodilator Agents - administration & dosage</subject><subject>Bronchodilator Agents - therapeutic use</subject><subject>Cross-Over Studies</subject><subject>Dose-Response Relationship, Drug</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>In vitro</subject><subject>Inhalation Spacers</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals</subject><subject>Middle Aged</subject><subject>Nebuchamber</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Plastics</subject><subject>Respiratory system</subject><subject>Salbutamol</subject><subject>Volumatic</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><recordid>eNqFkEtLxDAQgIMouj5-gtKLoodqJkmT1ovK4gtWPKjnkE2mEOm2NWkX_PdGd9Gjp8kM32RmPkIOgZ4DBXnxQrkq8wIUP6XsjFLOaa42yARKxXMulNwkk19kh-zG-E4plQz4NtkBxhRlQk7I9RMOpsmWGOIYs74xcfA2i72xqXKZmTbzbbb0Q-jS262SZZfZbtGb4GPX7pOt2jQRD9Zxj7zd3b5OH_LZ8_3j9GaWW17BkLPCGiGLSjk5Z0I4qGVtBEhLLYJiDkQlBUODNYJzc1mAKyuKQtVlCanG98jJ6t8-dB8jxkEvfLTYNKbFboxaMYBSAE9gsQJt6GIMWOs--IUJnxqo_lanf9Tpby-aMv2jTqvUd7QeMM4X6P661q4ScLwGTLSmqYNprY9_XLqzYqpI3NWKw6Rj6THoaD22Fp0PaAftOv_PKl9tqInu</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Janssen, R</creator><creator>Weda, M</creator><creator>Ekkelenkamp, M.B</creator><creator>Lammers, J-W.J</creator><creator>Zanen, P</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Metal versus plastic spacers: an in vitro and in vivo comparison</title><author>Janssen, R ; Weda, M ; Ekkelenkamp, M.B ; Lammers, J-W.J ; Zanen, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c391t-25ca46597d6b244d1f6fa416c0ce172d149642eaefe1ddb651d890e47f881fe13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Administration, Inhalation</topic><topic>Adult</topic><topic>Albuterol - administration & dosage</topic><topic>Albuterol - therapeutic use</topic><topic>Asthma - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Bronchodilation</topic><topic>Bronchodilator Agents - administration & dosage</topic><topic>Bronchodilator Agents - therapeutic use</topic><topic>Cross-Over Studies</topic><topic>Dose-Response Relationship, Drug</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>In vitro</topic><topic>Inhalation Spacers</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals</topic><topic>Middle Aged</topic><topic>Nebuchamber</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Plastics</topic><topic>Respiratory system</topic><topic>Salbutamol</topic><topic>Volumatic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Janssen, R</creatorcontrib><creatorcontrib>Weda, M</creatorcontrib><creatorcontrib>Ekkelenkamp, M.B</creatorcontrib><creatorcontrib>Lammers, J-W.J</creatorcontrib><creatorcontrib>Zanen, P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Janssen, R</au><au>Weda, M</au><au>Ekkelenkamp, M.B</au><au>Lammers, J-W.J</au><au>Zanen, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metal versus plastic spacers: an in vitro and in vivo comparison</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>245</volume><issue>1</issue><spage>93</spage><epage>98</epage><pages>93-98</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>This study compared the metal Nebuchamber® with the polycarbonate Volumatic® spacer in vivo as well as in vitro. Seventeen asthmatic patients were evaluated in a crossover placebo-controlled double-blind study. Bronchodilation, heart rate and serum potassium levels were measured at baseline and 15 min after administration of salbutamol. Cumulative dose-response curves (200, 400, 800 and 1600 μg) were constructed. The Andersen Cascade Impactor was used to compare the aerodynamic particle size distribution. The FEV
1 measurements showed highly significant differences between placebo and the two active preparations (
P<0.001), but not between the two active preparations (
P=0.433). The serum potassium levels also showed highly significant differences between placebo and the two active preparations (
P=0.009), but not between the two active preparations (
P=0.532). Only 1600 μg salbutamol dose raised the heart rate significantly, but the difference between the two active preparations was not significant. The in vitro deposition study revealed no significant differences in the delivered dose or in the fine particle dose (
P>0.05). In conclusion, there are no significant differences between the Volumatic® and Nebuchamber® either in vivo or in vitro.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12270246</pmid><doi>10.1016/S0378-5173(02)00330-7</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2002-10, Vol.245 (1), p.93-98 |
| issn | 0378-5173 1873-3476 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72118413 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Administration, Inhalation Adult Albuterol - administration & dosage Albuterol - therapeutic use Asthma - drug therapy Biological and medical sciences Bronchodilation Bronchodilator Agents - administration & dosage Bronchodilator Agents - therapeutic use Cross-Over Studies Dose-Response Relationship, Drug Double-Blind Method Female General pharmacology Humans In vitro Inhalation Spacers Male Medical sciences Metals Middle Aged Nebuchamber Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Plastics Respiratory system Salbutamol Volumatic |
| title | Metal versus plastic spacers: an in vitro and in vivo comparison |
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