The clinical value of measuring tissue factor activity in patients with cancer

The association between cancer and thromboembolic disease is well known. This relationship is complex and in many, perhaps most, malignant diseases acts through multiple pathways. Increased tissue factor expression by endothelial cells, monocytes or macrophages has been implicated as one of these pa...

Full description

Saved in:
Bibliographic Details
Published in:Medical hypotheses 2002-06, Vol.58 (6), p.521-522
Main Author: Lwaleed, B.A.
Format: Article
Language:English
Subjects:
Humans
Neoplasms - metabolism
ROC Curve
Thromboplastin - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The association between cancer and thromboembolic disease is well known. This relationship is complex and in many, perhaps most, malignant diseases acts through multiple pathways. Increased tissue factor expression by endothelial cells, monocytes or macrophages has been implicated as one of these pathways. As well as being found in the circulating blood, tissue factor is also found in urine in a lipid-associated form. Although urinary tissue factor might be independent from that found in the circulation, its levels may reflect the status of peripheral blood monocyte activation. Thus, measurements of monocyte and/or urinary tissue factor may be of clinical significance, particularly in cancer, where levels could be valuable for diagnosis and monitoring progression.
ISSN:0306-9877
1532-2777
DOI:10.1054/mehy.2001.1502