Serum carotenoid concentrations in US children and adolescents

• Published in: The American journal of clinical nutrition 2002-10, Vol.76 (4), p.818-827
• Main Authors: Ford, Earl S, Gillespie, Cathleen, Ballew, Carol, Sowell, Anne, Mannino, David M
• Format: Article
• Language: English
• Subjects: Adolescent; adolescents; African Americans; alpha-carotene; beta Carotene - analogs & derivatives; beta Carotene - blood; beta-carotene; beta-cryptoxanthin; Biological and medical sciences; Body Mass Index; C-reactive protein; Carotenoids - blood; Child; children; Children & youth; Cholesterol - blood; Cholesterol, HDL - blood; Cross-Sectional Studies; Cryptoxanthins; Diet; Female; females; high density lipoprotein; Human physiology applied to population studies and life conditions. Human ecophysiology; Humans; lutein; Lutein - blood; lycopene; Male; males; Medical sciences; Mexican Americans; National Health and Nutrition Examination Survey; Nutrition; Nutritional survey. Food supply and nutritional requirement; phytochemicals; Reference Values; risk; Sex Characteristics; United States; Vitamin A; Xanthophylls; zeaxanthin; Zeaxanthins
• ISSN: 0002-9165; 1938-3207
• DOI: 10.1093/ajcn/76.4.818

Background: Carotenoids, a class of phytochemicals, may affect the risk of several chronic conditions. Objective: Our objective was to describe the distributions and correlates of serum carotenoid concentrations in US children and adolescents. Design: Using data from the third National Health and Nutrition Examination Survey (1988–1994), a cross-sectional study, we examined the distributions of serum concentrations of α-carotene, β-carotene, β-cryptoxanthin, lutein and zeaxanthin, and lycopene among 4231 persons aged 6–16 y. Results: After adjustment for age, sex, race or ethnicity, poverty-income ratio, body mass index status, HDL- and non-HDL-cholesterol concentrations, C-reactive protein concentration, and cotinine concentration, only HDL-cholesterol (P < 0.001) and non-HDL-cholesterol (P < 0.001) concentrations were directly related to all carotenoid concentrations. Age (P < 0.001) and body mass index status (P < 0.001) were inversely related to all carotenoid concentrations except those of lycopene. Young males had slightly higher carotenoid concentrations than did young females, but the differences were significant only for lycopene concentrations (P = 0.029). African American children and adolescents had significantly higher β-cryptoxanthin (P < 0.001), lutein and zeaxanthin (P < 0.001), and lycopene (P = 0.006) concentrations but lower α-carotene (P < 0.001) concentrations than did white children and adolescents. Mexican American children and adolescents had higher α-carotene (P < 0.001), β-cryptoxanthin (P < 0.001), and lutein and zeaxanthin (P < 0.001) concentrations but lower lycopene (P = 0.001) concentrations than did white children and adolescents. C-reactive protein concentrations were inversely related to β-carotene (P < 0.001), lutein and zeaxanthin (P < 0.001), and lycopene (P = 0.023) concentrations. Cotinine concentrations were inversely related to α-carotene (P = 0.002), β-carotene (P < 0.001), and β-cryptoxanthin (P < 0.001) concentrations. Conclusion: These data show significant variations in serum carotenoid concentrations among US children and adolescents and may be valuable as reference ranges for this population.