Physical properties and blood compatibility of surface-modified segmented polyurethane by semi-interpenetrating polymer networks with a phospholipid polymer

Segmented polyurethanes, (SPU)s, are widely used in the biomedical fields because of their excellent mechanical property. However, when blood is in contact with the SPU, non-specific biofouling on the SPU occurs which reduces its mechanical property. To obtain novel blood compatible elastomers, the...

Full description

Saved in:
Bibliographic Details
Published in:Biomaterials 2002-12, Vol.23 (24), p.4881-4887
Main Authors: Morimoto, Nobuyuki, Iwasaki, Yasuhiko, Nakabayashi, Nobuo, Ishihara, Kazuhiko
Format: Article
Language:English
Subjects:
2-Methacryloyloxyethyl phosphorylcholine polymer
Blood compatibility
Blood Platelets - cytology
Blood Platelets - metabolism
Cell Adhesion
Electron Probe Microanalysis
Humans
Interpenetrating polymer networks
Materials Testing
Methacrylates - chemistry
Microscopy, Electron, Scanning
Models, Chemical
Phospholipids - chemistry
Phosphorylcholine - analogs & derivatives
Phosphorylcholine - chemistry
Polymers - chemistry
Polyurethanes - chemistry
Segmented polyurethane
Stress loading
Stress, Mechanical
Tensile Strength
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Segmented polyurethanes, (SPU)s, are widely used in the biomedical fields because of their excellent mechanical property. However, when blood is in contact with the SPU, non-specific biofouling on the SPU occurs which reduces its mechanical property. To obtain novel blood compatible elastomers, the surface of the SPU was modified with 2-methacryloyloxyethyl phosphorylcholine (MPC) by forming a semi-interpenetrating polymer network (semi-IPN). The SPU film modified by MPC polymer with the semi-IPN (MS-IPN film) was prepared by visible light irradiation of the SPU film in which the monomers were diffused. X-ray photoelectron spectroscopy confirmed that the MPC units were exposed on the MS-IPN film surface. The mechanical properties of the MS-IPN film characterized by tensile testing were similar to those of the SPU film. Platelet adhesion on MS-IPN films was also investigated before and after stress loading to determine the effects of the surface modification on the blood compatibility. Many platelets did adhere on the SPU film before and after stress loading. On the other hand, the MS-IPN film prevented platelet adhesion even after repeated stress loading.
ISSN:0142-9612
1878-5905
DOI:10.1016/S0142-9612(02)00246-6