Is reexcision in pediatric nonrhabdomyosarcoma soft tissue sarcoma necessary after an initial unplanned resection?

• Published in: Journal of pediatric surgery 2002-10, Vol.37 (10), p.1424-1429
• Main Authors: Chui, C.H., Spunt, S.L., Liu, T., Pappo, A.S., Davidoff, A.M., Rao, B.N., Shochat, S.J.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Chemotherapy, Adjuvant; Child; Child, Preschool; Combined Modality Therapy; Female; Follow-Up Studies; Histiocytoma, Benign Fibrous - surgery; Humans; Male; Medical sciences; Miscellaneous; Neoplasm Recurrence, Local - prevention & control; Neoplasm, Residual - pathology; Neoplasm, Residual - surgery; Pretreatment reexcision; Proportional Hazards Models; Reoperation - methods; Reoperation - statistics & numerical data; Retrospective Studies; Sarcoma - pathology; Sarcoma - surgery; Sarcoma, Synovial - surgery; soft tissue sarcoma; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Survival Analysis; Treatment Outcome
• ISSN: 0022-3468; 1531-5037
• DOI: 10.1053/jpsu.2002.35405

Purpose: The aim of this study was to determine the importance of pretreatment reexcision (PRE) of pediatric nonrhabdomyosarcoma soft tissue sarcoma (NRSTS) after initial unplanned resection. Methods: The authors retrospectively reviewed the records of 116 consecutive patients with surgically resected NRSTS treated at their institution between February 1978 and September 1999. Ninety-four (81.0%) patients had undergone unplanned resections before referral to their institution for further therapy. Demographic data, tumor characteristics, treatment administered, and outcomes were recorded. Results: Sixty-nine patients (73.4%) underwent PRE at a median interval after the initial unplanned resection of 29 days. Twenty-five patients were thought unsuitable for PRE because of the proximity to vital neurovascular bundles. Tumors deemed not feasible for PRE were more likely to be greater than 5 cm (P =.0094) and high grade (P =.0200). Tumor was found in 33 (47.8%) of the PRE specimens, and 24 of these patients (72.7%) were deemed disease free after achieving negative surgical margins. Residual tumor was more likely to be found after PRE in head and neck primary tumors than in trunk wall or extremity primary tumors (P =.0128). There were no local failures in the 60 PRE patients who achieved clear margins. The estimated 5-year event-free and 5-year overall survival rates in these 60 patients were 98.3% ± 2.0% and 98.2% ± 2.1%, respectively. Conclusions: Pretreatment reexcision should be performed whenever feasible in pediatric patients with NRSTS who had an initial unplanned resection. The proportion of patients with residual tumor in the PRE specimen is high, and negative microscopic margins can be achieved after PRE in most patients with residual tumor. Despite delay in obtaining a complete surgical resection, no local recurrences were seen. The possibility of NRSTS should be considered when resecting a soft tissue mass in children, and diagnostic incisional biopsy followed by wide local excision with negative microscopic margins should be the surgical goal. J Pediatr Surg 37:1424-1429. Copyright 2002, Elsevier Science (USA). All rights reserved.