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Renal Tubular Acidosis: A New Look at an Old Problem

Although the definition of renal tubular acidosis (RTA) is simple, understanding the physiologic basis underlying the various types of this clinical entity is much more difficult. The pathophysiology of this disorder is reviewed using the normal acid-base functions of the involved segments of the ne...

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Published in:	Clinical pediatrics 2001-10, Vol.40 (10), p.533-543
Main Authors:	Roth, Karl S., Chan, James C. M.
Format:	Article
Language:	English
Subjects:	Acidosis Acidosis, Renal Tubular - diagnosis Acidosis, Renal Tubular - etiology Acidosis, Renal Tubular - physiopathology Adolescent Algorithms Biological and medical sciences Child Child, Preschool Clinical trials Growth Disorders - etiology Humans Hydrogen-Ion Concentration Infant Infant, Newborn Kidney Tubules, Distal - physiology Kidney Tubules, Proximal - physiology Kidneys Medical disorders Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Pediatrics Physiological aspects Sodium-Bicarbonate Symporters - genetics Sodium-Bicarbonate Symporters - metabolism Tubulopathies
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description	Although the definition of renal tubular acidosis (RTA) is simple, understanding the physiologic basis underlying the various types of this clinical entity is much more difficult. The pathophysiology of this disorder is reviewed using the normal acid-base functions of the involved segments of the nephron as a guide to understanding. Clinical and laboratory features of the subtypes of RTA are addressed, and diagnosis and treatment discussed. New developments in the knowledge and understanding of the associated growth disturbances, mineral metabolism, and molecular biology of RTA are also reviewed to provide the most current view of this relatively common pediatric entity.
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M.</creatorcontrib><title>Renal Tubular Acidosis: A New Look at an Old Problem</title><title>Clinical pediatrics</title><addtitle>Clin Pediatr (Phila)</addtitle><description>Although the definition of renal tubular acidosis (RTA) is simple, understanding the physiologic basis underlying the various types of this clinical entity is much more difficult. The pathophysiology of this disorder is reviewed using the normal acid-base functions of the involved segments of the nephron as a guide to understanding. Clinical and laboratory features of the subtypes of RTA are addressed, and diagnosis and treatment discussed. 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Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. 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subjects	Acidosis Acidosis, Renal Tubular - diagnosis Acidosis, Renal Tubular - etiology Acidosis, Renal Tubular - physiopathology Adolescent Algorithms Biological and medical sciences Child Child, Preschool Clinical trials Growth Disorders - etiology Humans Hydrogen-Ion Concentration Infant Infant, Newborn Kidney Tubules, Distal - physiology Kidney Tubules, Proximal - physiology Kidneys Medical disorders Medical sciences Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Pediatrics Physiological aspects Sodium-Bicarbonate Symporters - genetics Sodium-Bicarbonate Symporters - metabolism Tubulopathies
title	Renal Tubular Acidosis: A New Look at an Old Problem
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