Left ventricular mass index increases in proportion to the progression of diabetic nephropathy in Type 2 diabetic patients

• Published in: Diabetes research and clinical practice 2001-12, Vol.54 (3), p.173-180
• Main Authors: Suzuki, Katsunori, Kato, Kiminori, Hanyu, Osamu, Nakagawa, Osamu, Aizawa, Yoshifusa
• Format: Article
• Language: English
• Subjects: Albuminuria; Albuminuria - pathology; Associated diseases and complications; Biological and medical sciences; Blood Pressure - physiology; Cardiovascular disease; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2 - pathology; Diabetes Mellitus, Type 2 - urine; Diabetes. Impaired glucose tolerance; Diabetic Nephropathies - pathology; Diabetic Nephropathies - urine; Diabetic nephropathy; Disease Progression; Electrocardiography; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Humans; Hypertrophy, Left Ventricular - etiology; Hypertrophy, Left Ventricular - urine; Left ventricular hypertrophy; Male; Medical sciences; Middle Aged; Multivariate Analysis; Regression Analysis; Type 2 DM; Urine - chemistry
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/S0168-8227(01)00318-7

The aim of our cross-sectional case-control study was to evaluate the mechanism of increased cardiac morbidity and mortality in Type 2 diabetic patients with normo-, micro-, and macroalbuminuria. Twenty-nine Type 2 diabetic patients with normoalbuminuria (group N), 19 patients with microalbuminuria (group M1), and seven patients with macroalbuminuria (group M2) were investigated. Groups were not significantly different concerning age, sex and diabetes duration. All patients took their normal medication throughout the study and had no clinical evidence of heart disease. Left ventricular mass index (LVMI) and systolic function were determined by echocardiography. As to the elevation of urinary albumin excretion levels, LVMI was significantly elevated, 101.4±20 gm −2 of group N, 119.5±29 gm −2 of group M1, and 141.9±27 gm −2 of group M2. The prevalence of left ventricular hypertrophy (LVH) was significantly higher in group M2 (100%), and M1 (58%), as compared with group N (24%), but was not significantly different between groups M1 and M2. The body mass index and systolic blood pressure were significant independent predictors of LVMI by multiple regression analysis. In conclusion, the mechanism of the link between albuminuria and cardiovascular mortality was suggested to be LVH.