Fibrinogen E-fragment inhibits the migration and tubule formation of human dermal microvascular endothelial cells in vitro

Angiogenesis, the development of new blood vessels from an existing vascular bed, is essential for the growth and spread of malignant tumors. Several endogenous angiogenesis inhibitors have been discovered and shown to suppress endothelial cell function in vitro and tumor growth in vivo. Several of...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 2000-09, Vol.60 (17), p.4719-4724
Main Authors: BOOTLE-WILBRAHAM, Carolyn A, TAZZYMAN, S, MARSHALL, J. M, LEWIS, Claire E
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cell Division - drug effects
Cell Movement - drug effects
Cells, Cultured
Collagen
Dissemination
Drug Combinations
Endothelial Growth Factors - antagonists & inhibitors
Endothelial Growth Factors - pharmacology
Endothelium, Vascular - cytology
Endothelium, Vascular - drug effects
Endothelium, Vascular - metabolism
Fibrin Fibrinogen Degradation Products - metabolism
Fibrin Fibrinogen Degradation Products - pharmacology
Fibrinogen - metabolism
Fibrinogen - pharmacology
Fibroblast Growth Factor 2 - pharmacology
Humans
Laminin
Lymphokines - antagonists & inhibitors
Lymphokines - pharmacology
Medical sciences
Neovascularization, Physiologic - drug effects
Proteoglycans
Skin - blood supply
Tumor cell
Tumors
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
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Summary:Angiogenesis, the development of new blood vessels from an existing vascular bed, is essential for the growth and spread of malignant tumors. Several endogenous angiogenesis inhibitors have been discovered and shown to suppress endothelial cell function in vitro and tumor growth in vivo. Several of these are proteolytic fragments of larger, endogenous proteins. Here we show that a Mr 50,000 polypeptide derived from the plasmin cleavage of fibrinogen, fibrinogen E-fragment, inhibits endothelial cell migration and tubule formation induced by both proangiogenic growth factors, vascular endothelial growth factor and basic fibroblast growth factor, in vitro.
ISSN:0008-5472
1538-7445