Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men

In sedentary humans endothelium-dependent vasodilation is impaired with advancing age contributing to their increased cardiovascular risk, whereas endurance-trained adults demonstrate lower age-related risk. We determined the influence of regular aerobic exercise on the age-related decline in endoth...

Full description

Saved in:
Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 2000-09, Vol.102 (12), p.1351-1357
Main Authors: DESOUZA, Christopher A, SHAPIRO, Linda F, CLEVENGER, Christopher M, DINENNO, Frank A, MONAHAN, Kevin D, TANAKA, Hirofumi, SEALS, Douglas R
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Adult
Aged
Aging - physiology
Anthropometry
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Cross-Sectional Studies
Endothelium, Vascular - physiology
Exercise - physiology
Forearm - blood supply
Humans
Male
Medical sciences
Middle Aged
Nitroprusside - pharmacology
Regional Blood Flow - drug effects
Running - physiology
Vasodilation - drug effects
Vasodilation - physiology
Vasodilator Agents - pharmacology
Vital Capacity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In sedentary humans endothelium-dependent vasodilation is impaired with advancing age contributing to their increased cardiovascular risk, whereas endurance-trained adults demonstrate lower age-related risk. We determined the influence of regular aerobic exercise on the age-related decline in endothelium-dependent vasodilation. In a cross-sectional study, 68 healthy men 22 to 35 or 50 to 76 years of age who were either sedentary or endurance exercise-trained were studied. Forearm blood flow (FBF) responses to intra-arterial infusions of acetylcholine and sodium nitroprusside were measured by strain-gauge plethysmography. Among the sedentary men, the maximum FBF response to acetylcholine was 25% lower in the middle aged and older compared with the young group (P:
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.102.12.1351