Drosophila Immune Deficiency (IMD) Is a Death Domain Protein that Activates Antibacterial Defense and Can Promote Apoptosis

We report the molecular characterization of the immune deficiency ( imd) gene, which controls antibacterial defense in Drosophila. imd encodes a protein with a death domain similar to that of mammalian RIP (receptor interacting protein), a protein that plays a role in both NF-κB activation and apopt...

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Bibliographic Details
Published in:Developmental cell 2001-10, Vol.1 (4), p.503-514
Main Authors: Georgel, Philippe, Naitza, Silvia, Kappler, Christine, Ferrandon, Dominique, Zachary, Daniel, Swimmer, Candace, Kopczynski, Casey, Duyk, Geoffrey, Reichhart, Jean-Marc, Hoffmann, Jules A.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - metabolism
Apoptosis - physiology
Bacterial Infections - immunology
Caspases - genetics
Caspases - metabolism
Chromosome Mapping
Cysteine Proteinase Inhibitors - metabolism
DmIKK protein
DNA Damage
DREDD protein
Drosophila - genetics
Drosophila - immunology
Drosophila melanogaster
Drosophila Proteins - chemistry
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Female
Gene Expression - immunology
I-kappa B Kinase
immune deficiency (imd) gene
Immunocompromised Host - genetics
In Situ Nick-End Labeling
Insect Proteins - genetics
Male
Molecular Sequence Data
Mutation - physiology
Phenotype
Protein Structure, Tertiary
Protein-Serine-Threonine Kinases - genetics
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Summary:We report the molecular characterization of the immune deficiency ( imd) gene, which controls antibacterial defense in Drosophila. imd encodes a protein with a death domain similar to that of mammalian RIP (receptor interacting protein), a protein that plays a role in both NF-κB activation and apoptosis. We show that imd functions upstream of the DmIKK signalosome and the caspase DREDD in the control of antibacterial peptide genes. Strikingly, overexpression of imd leads to constitutive transcription of these genes and to apoptosis, and both effects are blocked by coexpression of the caspase inhibitor P35. We also show that imd is involved in the apoptotic response to UV irradiation. These data raise the possibility that antibacterial response and apoptosis share common control elements in Drosophila.
ISSN:1534-5807
1878-1551
DOI:10.1016/S1534-5807(01)00059-4