Persistent maternally derived peripheral microchimerism is associated with the juvenile idiopathic inflammatory myopathies

Objective. Fetal cells have been demonstrated in the active lesions of adult women with systemic sclerosis. Because the juvenile idiopathic inflammatory myopathies (JIIM) share clinical and histopathological features with systemic sclerosis and graft‐vs‐host disease, we explored the possibility that...

Full description

Saved in:
Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2001-11, Vol.40 (11), p.1279-1284
Main Authors: Artlett, C. M., Miller, F. W., Rider, L. G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Child
Child, Preschool
Chimera - immunology
Dermatomyositis
Dermatomyositis - genetics
Dermatomyositis - immunology
Family Health
Female
Graft versus host reaction
Graft vs Host Reaction - immunology
HLA-C Antigens - immunology
Humans
Inflammatory myopathy
Male
Maternal-Fetal Exchange
Medical sciences
Microchimerism
Polymyositis
Pregnancy
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective. Fetal cells have been demonstrated in the active lesions of adult women with systemic sclerosis. Because the juvenile idiopathic inflammatory myopathies (JIIM) share clinical and histopathological features with systemic sclerosis and graft‐vs‐host disease, we explored the possibility that maternal cells persist and play a role in the pathogenesis of JIIM. Methods. DNA samples extracted from peripheral blood of 28 JIIM patients (14 females, 14 males) and 23 healthy controls were assessed for microchimerism by the HLA Cw polymerase chain reaction method. HLA Cw alleles from eight mothers and three healthy siblings of JIIM patients were also examined. Results. A microchimeric allele was identified in 19 of 26 JIIM patients whose data were able to be interpreted, compared with two of 21 healthy controls (P
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/40.11.1279