Tumor invasion is inhibited by phosphorylated ascorbate via enrichment of intracellular vitamin C and decreasing of oxidative stress

Tumor metastasis and invasion were shown to be inhibited by the 2-O-phosphorylated form (Asc2P) of L-ascorbic acid (Asc); intact Asc did not inhibit tumor invasion when added once, but appreciably inhibited it upon repeated addition. The anti-metastatic effect is attributable to a marked enrichment...

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Bibliographic Details
Published in:Journal of cancer research and clinical oncology 2000-09, Vol.126 (9), p.511-518
Main Authors: NAGAO, N, NAKAYAMA, T, ETOH, T, SAIKI, I, MIWA, N
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Antineoplastic Agents - pharmacokinetics
Antineoplastic Agents - therapeutic use
Ascorbic Acid - analogs & derivatives
Ascorbic Acid - metabolism
Ascorbic Acid - pharmacokinetics
Ascorbic Acid - therapeutic use
Biological and medical sciences
Cell Movement - drug effects
Chemotherapy
Extracellular Matrix - drug effects
Extracellular Matrix - metabolism
Female
Fibrosarcoma - drug therapy
Fibrosarcoma - prevention & control
Fibrosarcoma - secondary
Free Radical Scavengers
Humans
Medical sciences
Melanoma, Experimental - drug therapy
Melanoma, Experimental - prevention & control
Melanoma, Experimental - secondary
Mice
Mice, Inbred C57BL
Neoplasm Invasiveness - prevention & control
Neoplasm Metastasis - prevention & control
Oxidative Stress - drug effects
Pharmacology. Drug treatments
Reactive Oxygen Species - metabolism
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Description
Summary:Tumor metastasis and invasion were shown to be inhibited by the 2-O-phosphorylated form (Asc2P) of L-ascorbic acid (Asc); intact Asc did not inhibit tumor invasion when added once, but appreciably inhibited it upon repeated addition. The anti-metastatic effect is attributable to a marked enrichment of intracellular Asc by Asc2P, subsequently dephosphorylated. Asc2P scavenged most of the intracellular reactive oxygen species (ROSin), and notably inhibited production of matrix metalloproteases and cell motility. ROSin was decreased by Asc2P more markedly than by Asc added once. Thus, involvement of ROSin in tumor invasion and a potent anti-metastatic therapy by ROSin-decreasing agents are suggested.
ISSN:0171-5216
1432-1335
DOI:10.1007/s004320000120