Successful out-of-hospital cardiopulmonary resuscitation: what is the optimal in-hospital treatment strategy?

• Published in: Resuscitation 2000-10, Vol.47 (2), p.155-161
• Main Authors: Bulut, Suat, Aengevaeren, Wim R.M., Luijten, Hans J.E., Verheugt, Freek W.A.
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Analysis of Variance; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Angioplasty, Balloon, Coronary; Biological and medical sciences; Cardiopulmonary Resuscitation; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care; Female; Glasgow Coma Scale; Heart Arrest - mortality; Heart Arrest - therapy; Hospital Mortality; Humans; Intensive care medicine; Male; Medical sciences; Middle Aged; Myocardial Infarction - therapy; Netherlands - epidemiology; Out-of-hospital cardiopulmonary resuscitation; Outcome; Prognosis; Risk Factors; Thrombolytic Therapy
• ISSN: 0300-9572; 1873-1570
• DOI: 10.1016/S0300-9572(00)00217-3

The aim of the study was to evaluate prognostic factors in patients after successful out-of-hospital resuscitation (sOHR) within 30 min after admission. A prognostic scoring scale in patients surviving OHR was analysed. We also studied the effect of these predictive factors and the in-hospital treatment (percutaneous transluminal coronary angioplasty (PTCA) vs. thrombolysis) on mortality. We performed a retrospective analysis of the emergency medical system forms and medical files of 72 consecutive patients aged ≥18 years with sOHR. Of these 72 patients 37 (51%) met the electrocardiographic and enzymatic criteria for acute myocardial infarction (AMI). Ten of the 37 AMI patients (27%) underwent acute PTCA as primary treatment and seven patients (19%) received thrombolytic therapy for AMI despite prolonged (mean 24±13 min) cardiopulmonary resuscitation (CPR). The remaining 20 patients had no specific infarct treatment. Despite successful PTCA, in eight out of ten patients, their mortality in hospital was 60% (6/10). Mortality in the thrombolysis group was 57% (4/7). For the remaining 20 MI-patients the mortality was 65% (13/20). Univariate and multivariate analyses were performed to design a weighted prognostic scoring system. The Glasgow coma scale (GCS) was the strongest independent predictor ( r=0.76, P≤0.001) for in-hospital death. Conclusions: in-hospital mortality after successful OHR seems to largely depend on neurological status at admission and much less on the specific treatment of myocardial infarction. The prognostic scoring system accurately predicted the in-hospital mortality and can be used for early treatment stratification; however, it should be proven in a prospective study.