The Effect of Switching between Sequential and Repetitive Movements on Cortical Activation

• Published in: NeuroImage (Orlando, Fla.) Fla.), 2000-11, Vol.12 (5), p.528-537
• Main Authors: Jäncke, Lutz, Himmelbach, Marc, Shah, N.Jon, Zilles, Karl
• Format: Article
• Language: English
• Subjects: Adult; Attention - physiology; Brain Mapping; Brain research; Cerebral Cortex - physiology; Cortex; Dominance, Cerebral - physiology; Female; fMRI; Functional magnetic resonance imaging; hand movement; Humans; Magnetic Resonance Imaging; Male; Memory; Mental Recall - physiology; motor control; Motor Cortex - physiology; motor program; Motor task performance; movement sequences; pre-SMA; premotor cortex; Psychomotor Performance - physiology; Serial Learning - physiology; SMA; Stereotyped Behavior - physiology; Supplementary motor area; Visual stimuli
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1006/nimg.2000.0626

We used whole-head functional magnetic resonance imaging (fMRI) to investigate the effect of switching between different sequential and repetitive movements in the context of conditional and fixed tasks. Four different movement tasks were applied: (1) unpredictable switching between two movement sequences comprising six submovements each according to visual cues (SEQ-VC); (2) unpredictable switching between repetitive movement of one finger according to visual cues (REP-VC); (3) performance of the same sequential movements used for SEQ-VC but in a fixed mode triggered by a visual stimulus (SEQ-FIX); (4) performance of the repetitive movements used for REP-FIX but in a fixed mode by a visual stimulus (REP-FIX). The statistical group analysis of the hemodynamic responses revealed the following results: (1) the SEQ-VC compared to the SEQ-FIX condition (switching between movement sequences) engendered stronger activations in the left rostral supplementary motor area (pre-SMA), bilaterally in the posterior parietal lobule, the left ventral premotor area, and the visual cortices; (2) the REP-VC compared to the REP-FIX condition (switching between repetitive movements) only revealed stronger activation in extra-striate areas. We hypothesize that during switching of movement sequences higher motor control aspects are involved including movement selection, updating of motor plans, as well as recalling and restoring motor plans. The repetitive movements are too simple in order to evoke additional activations in the medial and lateral premotor areas, as well as in parietal areas.