Survival and neonatal morbidity at the limits of viability in the mid 1990s: 22 to 25 weeks

Objective: We determined neonatal survival and morbidity rates based on both fetal (stillborn) and neonatal deaths for infants delivered at 22 to 25 weeks’ gestation. Study design: Two hundred seventy-eight deliveries at 22 to 25 weeks’ completed gestation were analyzed by gestational age groups bet...

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Bibliographic Details
Published in:The Journal of pediatrics 2000-11, Vol.137 (5), p.616-622
Main Authors: El-Metwally, Dina, Vohr, Betty, Tucker, Richard
Format: Article
Language:English
Subjects:
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Emergency and intensive care: neonates and children. Prematurity. Sudden death
Female
Fetal Death - epidemiology
Gestational Age
Humans
Infant Mortality
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - mortality
Intensive care medicine
Intensive Care, Neonatal
Logistic Models
Medical sciences
Morbidity
Obstetric Labor, Premature
Perinatal Care
Pregnancy
Pregnancy Outcome
Resuscitation
Retrospective Studies
Survival Rate
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Summary:Objective: We determined neonatal survival and morbidity rates based on both fetal (stillborn) and neonatal deaths for infants delivered at 22 to 25 weeks’ gestation. Study design: Two hundred seventy-eight deliveries at 22 to 25 weeks’ completed gestation were analyzed by gestational age groups between January 1993 and December 1997. Logistic regression models were used to identify maternal and neonatal factors associated with survival. Results: The rate of fetal death was 24%; 76% of infants were born alive and 46% survived to discharge. Survival rates including fetal death at 22, 23, 24, and 25 weeks were 1.8%, 34%, 49%, and 76%; and survival rates excluding fetal death were 4.6%, 46%, 59%, and 82%, respectively. Logistic regression analyses showed that higher gestational age (P
ISSN:0022-3476
1097-6833
DOI:10.1067/mpd.2000.109143