Axial osteomalacia with sacroiliitis and moderate phosphate diabetes : Report of a case

• Published in: Clinical and experimental rheumatology 2000-09, Vol.18 (5), p.625-628
• Main Authors: CORTET, B, BERNIERE, L, SOLAU-GERVAIS, E, HACENE, A, COTTEN, A, DELCAMBRE, B
• Format: Article
• Language: English
• Subjects: Absorptiometry, Photon; Arthritis - complications; Arthritis - diagnostic imaging; Biological and medical sciences; Biomarkers; Bone Density; Bone Remodeling; Diseases of the osteoarticular system; Femur Neck - diagnostic imaging; Femur Neck - metabolism; Humans; Hypophosphatemia, Familial - complications; Hypophosphatemia, Familial - diagnostic imaging; Hypophosphatemia, Familial - metabolism; Male; Medical sciences; Middle Aged; Osteomalacia - complications; Osteomalacia - diagnostic imaging; Osteoporosis. Osteomalacia. Paget disease; Pelvic Bones - diagnostic imaging; Sacroiliac Joint - diagnostic imaging; Spine - diagnostic imaging
• ISSN: 0392-856X; 1593-098X

We report a new case of axial osteomalacia diagnosed in a 51-year-old white Caucasian male, made particular by its association with sacroiliitis, positive HLA-B27 antigen, and also moderate phosphate diabetes responsible for a decreased appendicular bone mass. The diagnosis was suspected when X-ray evaluation showed increased density and coarse trabeculation mainly involving the pelvis and spine. Dual energy X-ray absorptiometry confirmed the elevated bone density at the lumbar spine (T score: +1.92) contrasting with a decreased bone mass at the femoral neck (T score: -2.33). The diagnosis was confirmed by histomorphometry of the iliac crest showing marked thickening of the cortices (2190 microns +/- 0.574, N = 780 +/- 40) and an increased trabecular bone volume (33.24%, N = 14 +/- 3). Osteoid parameters were also markedly increased with an osteoid volume of 2.1% (N = 1.2 +/- 0.5) and a mean osteoid thickness of 28.7 microns (N = 13 +/- 2.5), with a normal bone fluoride content (0.082%, N < 0.10). Bone resorption as assessed on bone biopsy and by the measurement of markers of bone remodeling (serum procollagen type I C-terminal telopeptide and 24 hr urinary cross-laps to creatinine ratio) was increased. This latter finding was not necessarily due to axial osteomalacia and could be the consequence of moderate phosphate diabetes. The patient was treated with calcitriol which was promptly discontinued due to gastrointestinal symptoms and replaced by calcidiol without any significant effect on the low back pain.