Effects of stereotactic radiosurgery on metastatic brain tumors of various histopathologies

Although reports have been published describing clinical results in a large series of patients with metastatic brain tumors treated by stereotactic radiosurgery (SRS), clinical neuropathological correlation has rarely been available. The present paper describes three autopsy cases and one surgical c...

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Bibliographic Details
Published in:Neuropathology 2001-12, Vol.21 (4), p.307-314
Main Authors: Kamada, Kensaku, Mastuo, Takayuki, Tani, Masaharu, Izumo, Tsuyoshi, Suzuki, Yaeko, Okimoto, Tomoaki, Hayashi, Nobuyuki, Hyashi, Kuniaki, Shibata, Shobu
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adenocarcinoma - secondary
Adenocarcinoma - surgery
Adult
Aged
Brain Neoplasms - pathology
Brain Neoplasms - secondary
Brain Neoplasms - surgery
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - secondary
Carcinoma, Squamous Cell - surgery
Female
histopathology
Humans
Lung Neoplasms
Male
Melanoma - pathology
Melanoma - secondary
Melanoma - surgery
metastatic brain tumor
Osteosarcoma - pathology
Osteosarcoma - secondary
Osteosarcoma - surgery
radiosensitivity
Radiosurgery - statistics & numerical data
Rectal Neoplasms
stereotactic radiosurgery
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Summary:Although reports have been published describing clinical results in a large series of patients with metastatic brain tumors treated by stereotactic radiosurgery (SRS), clinical neuropathological correlation has rarely been available. The present paper describes three autopsy cases and one surgical case treated with linear accelerator based radiosurgery. The cases comprised a lung cancer, a rectal cancer, an osteosarcoma, and a malignant melanoma. Histological sections of each tumor were analyzed by light microscopy based on the Ohosi and Shimosato's histopathological classification of the effects of radiation therapy. In three cases (pulmonary squamous cell carcinoma, rectal adenocarcinoma and osteosarcoma), a large area of the tumors consisted of coagulation necrosis and non‐viable tumor cells, while coagulation necrosis and non‐viable tumor cells comprised a very small part of the malignant melanoma. Histopathological type of the metastatic brain tumor may be one of the factors influencing outcome after SRS.
ISSN:0919-6544
1440-1789
DOI:10.1046/j.1440-1789.2001.00404.x