Increased Arterial Intima-Media Thickness and In Vivo LDL Oxidation in Young Men With Borderline Hypertension

We used borderline hypertension as a model for prehypertension to examine the early influences of elevated blood pressure on subclinical atherosclerosis, lipoprotein oxidation, and cardiac adaptation. Healthy men (age 37±4 years) were classified prospectively into 2 groups on the basis of having eit...

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Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2000-12, Vol.36 (6), p.929-933
Main Authors: Toikka, Jyri O, Laine, Hanna, Ahotupa, Markku, Haapanen, Arto, Viikari, Jorma S. A, Hartiala, Jaakko J, Raitakari, Olli T
Format: Article
Language:English
Subjects:
Adult
Arterial hypertension. Arterial hypotension
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
Child
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Endothelium, Vascular - physiopathology
Humans
Hypertension - metabolism
Hypertension - pathology
Hypertension - physiopathology
Lipoproteins, LDL - metabolism
Male
Medical sciences
Oxidation-Reduction
Prospective Studies
Tunica Intima - pathology
Tunica Media - pathology
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container_title Hypertension (Dallas, Tex. 1979)
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creator Toikka, Jyri O
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description We used borderline hypertension as a model for prehypertension to examine the early influences of elevated blood pressure on subclinical atherosclerosis, lipoprotein oxidation, and cardiac adaptation. Healthy men (age 37±4 years) were classified prospectively into 2 groups on the basis of having either borderline hypertension (systolic 130 to 140 mm Hg or diastolic 85 to 89 mm Hg, n=16) or normal (
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Baseline low-density lipoprotein (LDL)-diene conjugation was measured as an estimate of in vivo LDL oxidation (ox-LDL). Compared with normotensive controls, men with borderline hypertension had higher IMT of the carotid artery (0.58±0.06 versus 0.75±0.07 mm, P &lt;0.001) and IMT of the brachial artery (0.45±0.05 versus 0.57±0.07 mm, P &lt;0.001), and increased levels of ox-LDL (29±9 versus 47±17 mol/L, P &lt;0.001), but similar endothelial function. Left ventricular mass was similar in both groups, but there were significant differences in left ventricular geometry. In multivariate analyses, the predictors of carotid IMT were 24-hour systolic blood pressure (P &lt;0.001) and ox-LDL (P =0.10). The current study demonstrates evidence of increased subclinical atherosclerosis and ox-LDL in borderline hypertension. 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Left ventricular mass was similar in both groups, but there were significant differences in left ventricular geometry. In multivariate analyses, the predictors of carotid IMT were 24-hour systolic blood pressure (P &lt;0.001) and ox-LDL (P =0.10). The current study demonstrates evidence of increased subclinical atherosclerosis and ox-LDL in borderline hypertension. These results are consistent with the idea that enhanced ox-LDL may be one of the pathophysiological events related to development of atherosclerosis in men with borderline elevated blood pressure.</abstract><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>11116102</pmid><doi>10.1161/01.HYP.36.6.929</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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ispartof Hypertension (Dallas, Tex. 1979), 2000-12, Vol.36 (6), p.929-933
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subjects Adult
Arterial hypertension. Arterial hypotension
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Pressure
Cardiology. Vascular system
Child
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Endothelium, Vascular - physiopathology
Humans
Hypertension - metabolism
Hypertension - pathology
Hypertension - physiopathology
Lipoproteins, LDL - metabolism
Male
Medical sciences
Oxidation-Reduction
Prospective Studies
Tunica Intima - pathology
Tunica Media - pathology
title Increased Arterial Intima-Media Thickness and In Vivo LDL Oxidation in Young Men With Borderline Hypertension
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