Glycine substitution mutations by different amino acids in the same codon of COL7A1 lead to heterogeneous clinical phenotypes of dominant dystrophic epidermolysis bullosa

Dystrophic epidermolysis bullosa (DEB), caused by mutations in the gene encoding type VII collagen (COL7A1), is known to show heterogeneous clinical phenotypes. Certain correlations between the nature or position of COL7A1 mutations and the resultant DEB phenotypes have been suggested, although such...

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Bibliographic Details
Published in:Archives of Dermatological Research 2000-10, Vol.292 (10), p.477-481
Main Authors: MURATA, Takayuki, MASUNAGA, Takuji, SHIMIZU, Hiroshi, TAKIZAWA, Yasuko, ISHIKO, Akira, HATTA, Naohito, NISHIKAWA, Takeji
Format: Article
Language:English
Subjects:
Adult
Amino Acid Substitution
Biological and medical sciences
Bullous diseases of the skin
Child
Codon
Collagen - analysis
Collagen - genetics
Dermatology
Epidermolysis Bullosa Dystrophica - genetics
Female
Glycine - genetics
Humans
Medical sciences
Mutation
Pedigree
Phenotype
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Description
Summary:Dystrophic epidermolysis bullosa (DEB), caused by mutations in the gene encoding type VII collagen (COL7A1), is known to show heterogeneous clinical phenotypes. Certain correlations between the nature or position of COL7A1 mutations and the resultant DEB phenotypes have been suggested, although such relationships may be more complex than initially thought. The purpose of the present study was to clarify the molecular basis of two different subtypes of dominant DEB (DDEB), EB pruriginosa and classical type. Interestingly, we found that both cases were caused by a missense glycine substitution mutation by different amino acids in the same codon of COL7A1 (G2028R and G2028A). These results further support the notion that different glycine substitution mutations in the same codon can lead to heterogeneous clinical phenotypes of DDEB, EB pruriginosa and classical type.
ISSN:0340-3696
1432-069X
DOI:10.1007/s004030000162