Screening the Brazilian flora for antihypertensive plant species for in vitro angiotensin-I-converting enzyme inhibiting activity

The evaluation of several antihypertensive activity of Brazilian plant species was performed using in vitro inhibition of the angiotensin I-converting enzyme (ACE). Nineteen species belonging to 13 families were investigated. Plants were selected based on their use as diuretics and on a chemosystema...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 2000-06, Vol.7 (3), p.245-250
Main Authors: Castro Braga, F., Wagner, H., Lombardi, J.A., Braga de Oliveira, A.
Format: Article
Language:English
Subjects:
Angiotensin I-converting enzyme
Angiotensin-Converting Enzyme Inhibitors - chemistry
antihypertensive activity
Antihypertensive Agents - chemistry
Brazil
Brazilian plant species
Chromatography, High Pressure Liquid
Humans
in vitro inhibition
Plant Extracts - chemistry
Plants, Medicinal
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Summary:The evaluation of several antihypertensive activity of Brazilian plant species was performed using in vitro inhibition of the angiotensin I-converting enzyme (ACE). Nineteen species belonging to 13 families were investigated. Plants were selected based on their use as diuretics and on a chemosystematic consideration. Extracts of the following species presented the highest ACE inhibition rate, at concentrations of 0.33 mg/ml: Ouratea semiserrata (Mart. & Nees) Engl, stems (68%), Cuphea cartagenesis (Jacq.) Macbride leaves (50 %) and Mansoa hirsuta DC. leaves (54 %). Some hypotheses about the nature of the compounds that may be responsible for the activity of these species are discussed in the paper.
ISSN:0944-7113
1618-095X
DOI:10.1016/S0944-7113(00)80011-2