Hypercortisolemia decreases dexamethasone half-life in rabbit

The pharmacokinetics of dexamethasone have been found to be related to endogenous hypothalamic-pituitary-adrenal (HPA) axis activity. Lower plasma dexamethasone levels in psychiatric patients (especially depressed) who are dexamethasone suppression test (DST) nonsuppressors have previously been repo...

Full description

Saved in:
Bibliographic Details
Published in:Journal of psychiatric research 2002-11, Vol.36 (6), p.423-428
Main Authors: Stokes, P.E, Stoll, P.M, Schluger, J.H, Lasley, B
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Animals
Anti-Inflammatory Agents - blood
Behavioral psychophysiology
Biological and medical sciences
Depression
Dexamethasone
Dexamethasone - blood
Dexamethasone half-life
DST
Fundamental and applied biological sciences. Psychology
Hormones and behavior
Hydrocortisone - blood
Hypercortisolemia
Hypothalamo-Hypophyseal System - metabolism
Male
Medical sciences
Mood disorders
Pituitary-Adrenal System - metabolism
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Psychopathology. Psychiatry
Rabbits
Random Allocation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The pharmacokinetics of dexamethasone have been found to be related to endogenous hypothalamic-pituitary-adrenal (HPA) axis activity. Lower plasma dexamethasone levels in psychiatric patients (especially depressed) who are dexamethasone suppression test (DST) nonsuppressors have previously been reported. Since DST nonsuppression is one measure of HPA axis hyperactivity and is usually associated with relatively increased plasma cortisol levels and lower post dose plasma dexamethasone levels, we hypothesized that hypercortisolemia can induce a more rapid disappearance of dexamethasone from plasma. We therefore studied the kinetics of dexamethasone in rabbits before and after a period of sustained hypercortisolemia produced by administration of IM hydrocortisone acetate, a slowly absorbed salt of cortisol. Mean dexamethasone half-life decreased significantly from baseline of 1.92 h on day zero in seven rabbits to 1.17 h on experimental day 17 of induced hypercortisolemia ( P
ISSN:0022-3956
1879-1379
DOI:10.1016/S0022-3956(02)00012-2