Effects of hyaluronan on the healing of rabbit meniscus injured in the peripheral region

The effect of hyaluronan (hyaluronic acid; HA) on the healing of rabbit meniscus injured in the peripheral region was assessed. A longitudinal tear was created in the peripheral region of the medial meniscus in 20 mature New Zealand white rabbits. One week after surgery, HA was injected into the lef...

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Bibliographic Details
Published in:Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association 2000-11, Vol.5 (6), p.579-584
Main Authors: Ishima, Masahiro, Wada, Yuichi, Sonoda, Masaki, Harada, Yoshitada, Katsumi, Akira, Moriya, Hideshige
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - pharmacology
Animals
Biological and medical sciences
Diseases of the osteoarticular system. Orthopedic treatment
Hyaluronan
Hyaluronic Acid - pharmacology
Knee
Knee joint
Male
Medical sciences
Meniscal healing
Meniscal injury
Meniscus
Rabbits
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Sports injuries
Tibial Meniscus Injuries
Wound healing
Wound Healing - drug effects
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Summary:The effect of hyaluronan (hyaluronic acid; HA) on the healing of rabbit meniscus injured in the peripheral region was assessed. A longitudinal tear was created in the peripheral region of the medial meniscus in 20 mature New Zealand white rabbits. One week after surgery, HA was injected into the left knee joint once a week for 5 weeks (HA group), while saline was injected into the right knee (control group). Six and 12 weeks after surgery, gross morphology, histology, and biochemical evaluations were performed. On gross morphological examination, there was evidence of meniscal healing in both groups, but the healing rate of the HA group was significantly higher than that of the control group at 12 weeks. Histologically, meniscal healing started at the tibial portion of the meniscal injury at 6 weeks in both groups, then advanced in the direction of the femoral surface at 12 weeks in the HA group. Biochemically, water and glycosaminoglycan contents did not differ significantly between the two groups. Hyaluronan maintained the healing process of the injured menisci, especially in the femoral surface, up to 12 weeks after injury.
ISSN:0949-2658
1436-2023
DOI:10.1007/s007760070009