Lack of effect of α- and β-adrenergic inhibition on forearm glucose uptake despite differences in forearm blood flow in healthy humans

Insulin has both sympathoexcitatory and vasodilatory actions. It is unclear how these interact to affect muscular glucose uptake. The current study was designed to determine the systemic and local contributions of alpha- and beta-adrenergic activity to muscle glucose uptake. Forearm blood flow (FBF,...

Full description

Saved in:
Bibliographic Details
Published in:Metabolism, clinical and experimental clinical and experimental, 2002-11, Vol.51 (11), p.1506-1513
Main Authors: HOFFMAN, R. P, SINKEY, C. A, DOPP, J. M, PHILLIPS, B. G
Format: Article
Language:English
Subjects:
Adrenergic alpha-Antagonists - pharmacology
Adrenergic beta-Antagonists - pharmacology
Adult
Biological and medical sciences
Blood Glucose - metabolism
Carbohydrates
Epinephrine - blood
Female
Forearm
Fundamental and applied biological sciences. Psychology
Glucose - metabolism
Humans
Lactic Acid - blood
Male
Metabolisms and neurohumoral controls
Muscle, Skeletal - blood supply
Muscle, Skeletal - metabolism
Norepinephrine - blood
Phentolamine - pharmacology
Propranolol - pharmacology
Prospective Studies
Reference Values
Regional Blood Flow
Time Factors
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Insulin has both sympathoexcitatory and vasodilatory actions. It is unclear how these interact to affect muscular glucose uptake. The current study was designed to determine the systemic and local contributions of alpha- and beta-adrenergic activity to muscle glucose uptake. Forearm blood flow (FBF, plethysmography), arterial-venous glucose difference (AV-diff), and forearm glucose uptake (FGU) were measured during a 40-mU/m(2)/min insulin infusion with 120 minutes of euglycemia in 6 normal subjects (age, 28.8 +/- 4.9 years, mean +/- SD). Each subject was studied 5 times, once each with intravenous propranolol (IV PROP, 80 microg/min), intravenous phentolamine (IV PHEN, 500 microg/min), intra-arterial propranolol (IA PROP, 25 microg/min), intra-arterial phentolamine (IA PHEN, 12 microg/min/100 mL forearm tissue), and saline (SAL). FBF did not change during insulin with SAL, IA PROP, or IV PROP, but increased during insulin with IA PHEN and IV PHEN (P
ISSN:0026-0495
1532-8600
DOI:10.1053/meta.2002.35588