Effects of chronic electroconvulsive shock on interstitial concentrations of dopamine in the nucleus accumbens

There is accumulating evidence that chronic electroconvulsive shock (ECS) can increase the functional output of central dopaminergic systems. The present experiments investigated the effects of acute and chronic ECS on interstitial concentrations of dopamine (DA) in the nucleus accumbens (NAC) using...

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Bibliographic Details
Published in:Psychopharmacologia 1991-01, Vol.105 (2), p.230-238
Main Authors: NOMIKOS, G. G, ZIS, A. P, DAMSMA, G, FIBIGER, H. C
Format: Article
Language:English
Subjects:
3,4-Dihydroxyphenylacetic Acid - metabolism
Amphetamine - pharmacology
Animals
Apomorphine - pharmacology
Behavior, Animal - drug effects
Biological and medical sciences
Cholinergic system
Dopamine - metabolism
Electroshock
Homovanillic Acid - metabolism
Hydroxyindoleacetic Acid - metabolism
Male
Medical sciences
Motor Activity - drug effects
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Nucleus Accumbens - drug effects
Nucleus Accumbens - metabolism
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
Receptors, Dopamine - drug effects
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Summary:There is accumulating evidence that chronic electroconvulsive shock (ECS) can increase the functional output of central dopaminergic systems. The present experiments investigated the effects of acute and chronic ECS on interstitial concentrations of dopamine (DA) in the nucleus accumbens (NAC) using in vivo microdialysis in awake freely moving rats. ECS (150 V, 0.75 s) increased interstitial concentrations of DA, DOPAC and HVA to approximately 130% of baseline values. The magnitude of the ECS-induced increase in DA was not affected by chronic ECS. In contrast, the response of the DA metabolites was attenuated in the chronic ECS group. Chronic ECS did not influence apomorphine (25 micrograms/kg, SC)-induced decreases in extracellular concentrations of DA or its metabolites in the NAC, thus providing no support for the hypothesis that chronic ECS produces subsensitivity of DA autoreceptors. d-Amphetamine (1.5 mg/kg SC)-induced increases in extracellular DA were significantly prolonged in the NAC of the chronic ECS group. In accordance with previous reports, the locomotor stimulant effects of d-amphetamine were also enhanced in the chronic ECS group. These data provide further evidence that chronic ECS can increase certain behavioral and neurochemical indices of meso-accumbens DA function.
ISSN:0033-3158
1432-2072
DOI:10.1007/bf02244315