Relation of aortic distensibility determined by magnetic resonance imaging in patients ≥60 years of age to systolic heart failure and exercise capacity

Aortic stiffness increases with advancing age and is associated with the age-related decline in exercise capacity in healthy persons. Previous studies have suggested that aortic compliance is reduced in heart failure (HF). Older persons with systolic HF can have particularly severe exercise intolera...

Full description

Saved in:
Bibliographic Details
Published in:The American journal of cardiology 2002-12, Vol.90 (11), p.1221-1225
Main Authors: Rerkpattanapipat, Pairoj, Hundley, W.Gregory, Link, Kerry M., Brubaker, Peter H., Hamilton, Craig A., Darty, Stephen N., Morgan, Timothy M., Kitzman, Dalane W.
Format: Article
Language:English
Subjects:
Adult
Aged
Aging - physiology
Aorta - physiology
Aorta - physiopathology
Aortic Diseases - complications
Aortic Diseases - diagnosis
Biological and medical sciences
Cardiology. Vascular system
Ergometry
Exercise Tolerance - physiology
Female
Heart
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Oxygen Consumption
Risk Factors
Systole - physiology
Ventricular Function, Left - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aortic stiffness increases with advancing age and is associated with the age-related decline in exercise capacity in healthy persons. Previous studies have suggested that aortic compliance is reduced in heart failure (HF). Older persons with systolic HF can have particularly severe exercise intolerance. However, the relation between increased aortic stiffness and exercise intolerance in elderly patients with systolic HF has not been examined. Therefore, aortic distensibility of the proximal ascending aorta (assessed by magnetic resonance imaging) and exercise tolerance (assessed by maximal exercise ergometry with expired gas analysis) was measured in 28 subjects (10 healthy subjects aged 20 to 30 years, 10 healthy subjects aged ≥60 years, and 8 subjects aged ≥60 years with systolic HF). Compared with healthy older subjects, patients with systolic HF had markedly decreased distensibility of the proximal aorta (0.5 ± 0.4 vs 2.2 ± 1.2 10 −3 mm Hg −1, p
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(02)02838-2