Hepatitis C in the setting of HIV co-infection

Hepatitis C virus (HCV) co-infection is common among HIV-infected individuals and can lead to increased morbidity and mortality in this population. HIV adversely impacts the natural history of HCV disease with higher rates of liver disease progression but the effect of HCV on the natural history of...

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Bibliographic Details
Published in:Microbes and infection 2002-10, Vol.4 (12), p.1247-1251
Main Authors: Khalili, Mandana, Behm, Brian W.
Format: Article
Language:English
Subjects:
Antiviral Agents - therapeutic use
Biological and medical sciences
Co-infection
Hepatitis C
Hepatitis C - complications
Hepatitis C - drug therapy
Hepatitis C - epidemiology
Hepatitis C - mortality
Hepatitis C treatment
HIV
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - mortality
Human viral diseases
Humans
Infectious diseases
Interferon
Interferons - therapeutic use
Medical sciences
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
Viral hepatitis
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Summary:Hepatitis C virus (HCV) co-infection is common among HIV-infected individuals and can lead to increased morbidity and mortality in this population. HIV adversely impacts the natural history of HCV disease with higher rates of liver disease progression but the effect of HCV on the natural history of HIV is disputed. Additionally, presence of HCV may decrease tolerability of highly active antiretroviral regimens for HIV treatment due to a potential increase in hepatotoxicity. Currently there is limited information available regarding HCV therapy in the setting of HIV co-infection but the HCV virologic response to interferon regimens appears to be similar to those individuals with HCV infection alone. However, additional information is required to assess the efficacy and safety of HCV therapy including possible interaction of HCV and HIV anti-viral medications in these co-infected individuals.
ISSN:1286-4579
1769-714X
DOI:10.1016/S1286-4579(02)01652-0