A potential role for the mast cell in the pathogenesis of idiopathic osteoporosis in men

Osteoporosis is increasingly being recognized in men. Secondary causes are often implicated, but the mechanism of bone loss remains unclear in about a third of patients. The mast cell is a complex cell that stores a number of factors known to affect bone metabolism. Patients with systemic mastocytos...

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Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 2002-11, Vol.31 (5), p.556-561
Main Authors: Brumsen, C, Papapoulos, S.E, Lentjes, E.G.W.M, Kluin, P.M, Hamdy, N.A.T
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis of Variance
Biological and medical sciences
Bone Density - physiology
Bone Marrow - metabolism
Bone Marrow - pathology
Bone marrow biopsy
Bone marrow mast cells
Bone mineral density (BMD)
Diseases of the osteoarticular system
Humans
Idiopathic male osteoporosis
Male
Mast Cells - metabolism
Mast Cells - pathology
Mastocytosis - metabolism
Mastocytosis - pathology
Medical sciences
Methylhistamines - urine
Middle Aged
Osteoporosis - metabolism
Osteoporosis - pathology
Osteoporosis. Osteomalacia. Paget disease
Pathogenesis
Urine excretion N-methylhistamine
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Summary:Osteoporosis is increasingly being recognized in men. Secondary causes are often implicated, but the mechanism of bone loss remains unclear in about a third of patients. The mast cell is a complex cell that stores a number of factors known to affect bone metabolism. Patients with systemic mastocytosis often demonstrate osteoporosis and bone marrow mast cells may be increased in osteoporotic postmenopausal women. We address the possible role of the mast cell in the pathophysiology of male osteoporosis by studying the relationship between bone marrow infiltration with mast cells and the 24 h urine excretion of N-methylhistamine, and the severity of osteoporosis in 48 consecutive men with idiopathic osteoporosis (bone mineral density Z score of
ISSN:8756-3282
1873-2763
DOI:10.1016/S8756-3282(02)00875-X