Clinical applications of a non-invasive ICP monitoring method

Background and purpose: Until now the assessment of intracranial pressure (ICP) requires invasive methods. A previously introduced mathematical model allowed the non-invasive estimation of ICP (nICP) from arterial blood pressure (ABP) and blood flow velocity (FV). In various studies we have investig...

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Bibliographic Details
Published in:European journal of ultrasound 2002-11, Vol.16 (1), p.37-45
Main Authors: Schmidt, Bernhard, Klingelhöfer, Jürgen
Format: Article
Language:English
Subjects:
Arterial blood pressure
Blood Flow Velocity
Blood Pressure
Brain - physiopathology
Cerebral blood flow velocity
Cerebrovascular Circulation
Craniocerebral Trauma - diagnostic imaging
Craniocerebral Trauma - physiopathology
Hemodynamics
Homeostasis
Humans
Hydrocephalus - diagnostic imaging
Hydrocephalus - physiopathology
Impulse response function
Intracranial Pressure
Models, Theoretical
Stroke - diagnostic imaging
Stroke - physiopathology
Transcranial Doppler ultrasonography
Ultrasonography, Doppler, Transcranial
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Summary:Background and purpose: Until now the assessment of intracranial pressure (ICP) requires invasive methods. A previously introduced mathematical model allowed the non-invasive estimation of ICP (nICP) from arterial blood pressure (ABP) and blood flow velocity (FV). In various studies we have investigated the accuracy of this method and possible clinical applications. Methods and results: Selected hemodynamic parameters, calculated from the cerebral blood FV and the ABP curves, were used to express the relationship between ABP input and ICP output by linear transformation rules. In several clinical studies the accuracy and possible benefits of this method of non-invasive ICP (nICP) assessment were investigated. Assessment of ICP plateau waves: In 17 severely head injured patients we verified this model by comparison of nICP and measured ICP during generation of plateau waves, recorded in seven of these patients. In all simulations plateau elevations of ICP were well replicated. The correlation coefficient between increase of nICP and real ICP was R=0.98; P
ISSN:0929-8266
DOI:10.1016/S0929-8266(02)00044-7