Blood vessels and nerves: together or not?

These relations do not seem to apply in adult skin. Nerves and blood vessels only interact deep in the dermis where sympathetic and peptidergic axons modify cutaneous perfusion. The cutaneous axons that proliferate in embryonic skin, presumably under the influence of neurotropins produced by keratin...

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Bibliographic Details
Published in:The Lancet (British edition) 2002-11, Vol.360 (9347), p.1714-1714
Main Authors: Hogg, Philip J, McLachlan, Elspeth M
Format: Article
Language:English
Subjects:
Animals
Blood vessels
Blood Vessels - growth & development
Blood Vessels - physiology
Cellular biology
Endothelial Growth Factors - genetics
Endothelial Growth Factors - physiology
Epidermis
Humans
Intercellular Signaling Peptides and Proteins - genetics
Intercellular Signaling Peptides and Proteins - physiology
Lymphokines - genetics
Lymphokines - physiology
Nervous System Physiological Phenomena
Neurons
Psoriasis
Skin diseases
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
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Summary:These relations do not seem to apply in adult skin. Nerves and blood vessels only interact deep in the dermis where sympathetic and peptidergic axons modify cutaneous perfusion. The cutaneous axons that proliferate in embryonic skin, presumably under the influence of neurotropins produced by keratinocytes,6 later retract to become mechanosensors in the dermis.5 In adult skin, the epidermis is supplied by peptidergic (trkA+) nociceptors that are also important for its maintenance and repair.7 Angiogenesis clearly precedes reinnervation during healing of adult skin.8 Peptidergic and sympathetic axons proliferate in wounds,7 reflecting the overproduction of nerve growth factor that also leads to endothelial cell proliferation and inflammation.' The new axons retract as the scar resolves. Neurotropin-mediated interactions between these cell types are also thought to play a role in psoriasis and other skin lesions.6 By contrast with embryonic skin, the growth and branching of nerves and blood vessels in adult skin appears to be largely independent and driven by local factors.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(02)11726-0