IL‐18 Production in Human Pulmonary and Pleural Tuberculosis

Interleukin‐18 (IL‐18) has multiple important pro‐inflammatory effects, including the induction of interferon‐γ (IFN‐γ) in various diseases. In this study, we investigated the IL‐18‐producing activities in human pulmonary and pleural tuberculosis (TB) in response to purified protein derivative (PPD)...

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Published in:Scandinavian journal of immunology 2002-12, Vol.56 (6), p.611-618
Main Authors: Song, C.‐H., Lee, J.‐S., Nam, H.‐H., Kim, J.‐M., Suhr, J.‐W., Jung, S.‐S., Na, M.‐J., Paik, T.‐H., Kim, H.‐J., Park, J.‐K., Jo, E.‐K.
Format: Article
Language:English
Subjects:
Cells, Cultured
Epithelium - immunology
Humans
Interferon-gamma - biosynthesis
Interleukin-18 - biosynthesis
Interleukin-18 - genetics
Leukocytes, Mononuclear - immunology
Pleural Effusion - immunology
Pleurisy - immunology
Protein Precursors - biosynthesis
Protein Precursors - genetics
RNA, Messenger - biosynthesis
Tuberculin - immunology
Tuberculosis, Pleural - immunology
Tuberculosis, Pleural - pathology
Tuberculosis, Pulmonary - immunology
Up-Regulation
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Summary:Interleukin‐18 (IL‐18) has multiple important pro‐inflammatory effects, including the induction of interferon‐γ (IFN‐γ) in various diseases. In this study, we investigated the IL‐18‐producing activities in human pulmonary and pleural tuberculosis (TB) in response to purified protein derivative (PPD) antigen (Ag) from Mycobacterium tuberculosis. The most significant IL‐18 production was found in chronic refractory TB (CRTB) patients. However, IFN‐γ production in CRTB patients was significantly less than that in healthy tuberculin reactors or in patients with tuberculous pleurisy (TBP). Elevated levels of both IL‐18 and IFN‐γ were found in pleural fluids from TBP patients. In vitro production of IL‐18 was dramatically decreased following an 18 h stimulation with PPD. However, IFN‐γ was markedly increased in pleural mononuclear cells from TBP patients after in vitro stimulation with PPD. The mesothelial cell type was the main source of pro‐IL‐18 in pleural cells from TBP patients, suggesting an important role for these cells in TBP. Taken together, these data indicate that IL‐18 is elevated in peripheral blood mononuclear cells from CRTB patients, as well as at the site of TBP, indicating a possible role for IL‐18 in both protective immunity and pathologic responses in human TB.
ISSN:0300-9475
1365-3083
DOI:10.1046/j.1365-3083.2002.01143.x