Immunogenicity and safety of an adjuvanted influenza vaccine in patients with decompensated cirrhosis

The immunogenicity and tolerability of an adjuvanted trivalent influenza vaccine was evaluated in 20 patients with cirrhosis due to chronic HBV or HCV infections and eight healthy age matched controls. Seroconversion or a four-fold or greater increase in HI antibody titres to each antigen occurred i...

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Bibliographic Details
Published in:Vaccine 2002-12, Vol.20, p.B33-B35
Main Authors: Gaeta, Giovanni B, Stornaiuolo, Gianfranca, Precone, Davide F, Amendola, Antonella, Zanetti, Alessandro R
Format: Article
Language:English
Subjects:
Aged
Antibodies, Viral - biosynthesis
Antibodies, Viral - blood
Cirrhosis
Drug Administration Schedule
Female
Hepatitis A - complications
Hepatitis B virus
Hepatitis B, Chronic - complications
Hepatitis C virus
HIV Seropositivity - complications
Humans
Influenza vaccination
Influenza Vaccines - adverse effects
Influenza Vaccines - immunology
Liver Cirrhosis - complications
Male
Middle Aged
Vaccines, Virosome - adverse effects
Vaccines, Virosome - immunology
Virosomal vaccine
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Summary:The immunogenicity and tolerability of an adjuvanted trivalent influenza vaccine was evaluated in 20 patients with cirrhosis due to chronic HBV or HCV infections and eight healthy age matched controls. Seroconversion or a four-fold or greater increase in HI antibody titres to each antigen occurred in 75–85% of the patients and in 100% of the controls. One month after vaccination, the geometric mean antibody titres were significantly higher than baseline in both groups of vaccinees. A mild and transient erythema at the inoculation site was the only side effect for both groups. The results justify the use of an adjuvanted influenza vaccine, given as single-dose, in patients with advanced liver disease.
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(02)00510-8