Selectin-P and interleukin-8 plasma levels in coronary heart disease patients

Background  Alterations of the immune system are now believed to play crucial role in the pathogenesis of atherosclerosis. The aim of this study was analysis of soluble forms of selectin‐P and interleukin‐8 levels in patients with different form of coronary heart disease. Materials and methods: In t...

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Published in:European journal of clinical investigation 2002-09, Vol.32 (9), p.657-661
Main Authors: Romuk, E., Skrzep-Poloczek, B., Wojciechowska, C., Tomasik, A., Birkner, E., Wodniecki, J., Gabrylewicz, B., Ochala, A., Tendera, M.
Format: Article
Language:English
Subjects:
Aged
Angina, Unstable - immunology
Atherosclerosis
Biomarkers - blood
Case-Control Studies
Coronary Disease - immunology
coronary heart disease
endothelial cells
Enzyme-Linked Immunosorbent Assay - methods
Humans
interleukin-8
Interleukin-8 - blood
Male
Middle Aged
P-Selectin - blood
soluble selectin-P
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Summary:Background  Alterations of the immune system are now believed to play crucial role in the pathogenesis of atherosclerosis. The aim of this study was analysis of soluble forms of selectin‐P and interleukin‐8 levels in patients with different form of coronary heart disease. Materials and methods: In the study took part 18 patients with stable coronary heart disease, 20 patients with unstable coronary heart disease and 15 healthy persons from control group. Soluble selectin‐P and interleukin‐8 levels were measured in EDTA plasma with the use of enzyme immunoassay ELISA. Results The level of soluble selectin‐P was significantly higher in unstable coronary heart disease patients in comparison to the stable coronary heart disease patients (P ≤ 0·01) and nonsignificantly higher in comparison to the control group. The level of interleukin‐8 were significantly higher in unstable coronary heart disease patients in comparison to the stable coronary heart disease patients (P ≤ 0·01) and in comparison to the control group (P ≤ 0·02). Conclusion: Our findings suggest that soluble form of selectin‐P and interleukin‐8 may be useful clinical predictors of unstable coronary heart disease. The assessment of the risk for the development of coronary heart disease requires further serial investigation.
ISSN:0014-2972
1365-2362
DOI:10.1046/j.1365-2362.2002.01053.x