Altering electrical connections in the nervous system of the pteropod mollusc Clione limacina by neuronal injections of gap junction mRNA

Neurons can communicate with each other either via exchange of specific molecules at synapses or by direct electrical connections between the cytoplasm of either cell [for review see Bruzzone et al. (1996) Eur. J. Biochem., 238, 1–27]. Although electrical connections are abundant in many nervous sys...

Full description

Saved in:
Bibliographic Details
Published in:The European journal of neuroscience 2002-12, Vol.16 (12), p.2475-2476
Main Authors: Kelmanson, Ilya V., Shagin, Dmitry A., Usman, Natalia, Matz, Mikhail V., Lukyanov, Sergey A., Panchin, Yury V.
Format: Article
Language:English
Subjects:
Animals
Brain - cytology
Brain - growth & development
Brain - metabolism
Cell Communication - drug effects
Cell Communication - genetics
Clione limacina
connexin
Connexins - genetics
Ganglia, Invertebrate - cytology
Ganglia, Invertebrate - growth & development
Ganglia, Invertebrate - metabolism
gap junction
Gap Junctions - drug effects
Gap Junctions - metabolism
innexin
Membrane Potentials - drug effects
Membrane Potentials - genetics
Molecular Sequence Data
Mollusca
Mollusca - cytology
Mollusca - growth & development
Mollusca - physiology
Neural Pathways - cytology
Neural Pathways - growth & development
Neural Pathways - metabolism
Neurons - cytology
Neurons - drug effects
Neurons - metabolism
Organ Culture Techniques
pannexin
RNA, Messenger - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neurons can communicate with each other either via exchange of specific molecules at synapses or by direct electrical connections between the cytoplasm of either cell [for review see Bruzzone et al. (1996) Eur. J. Biochem., 238, 1–27]. Although electrical connections are abundant in many nervous systems, little is known about the mechanisms which govern the specificity of their formation. Recent cloning of the innexins – gap junction proteins responsible for electrical coupling in invertebrates (Phelan et al. (1998) Trends Genet., 14, 348–349], has made it possible to study the molecular mechanisms of patterning of the electrical connections between individual neurons in model systems. Here we demonstrate that intracellular injection of mRNA encoding the molluscan innexin Panx1 (Panchin et al. 2000 Curr. Biol., 10, R473‐R474) drastically alters the specificity of electrical coupling between identified neurons of the pteropod mollusc Clione limacina.
ISSN:0953-816X
1460-9568
DOI:10.1046/j.1460-9568.2002.02423.x