Identification of Isolated and Early Prostatic Adenocarcinoma in Radical Prostatectomy Specimens with Correlation to Biopsy Cores: Clinical and Pathogenetic Significance

Prostatic adenocarcinoma (PAC) is a multifocal disease. In this study, we identified isolated and small foci of PAC (ISPAC) in radical prostatectomy specimens, described the histopathologic features, investigated their zonal distribution in the prostate and their relationship with large tumor nodule...

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Bibliographic Details
Published in:Pathology, research and practice research and practice, 2002, Vol.198 (10), p.655-663
Main Authors: Mai, Kien T., Landry, Denise C., Yazdi, Hossein M., Stinson, William A., Perkins, D. Garth, Morash, Christopher
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Aged
Core biopsy
Early prostatic adenocarcinoma
Humans
Male
Middle Aged
Prostate
Prostatectomy
Prostatic Intraepithelial Neoplasia - pathology
Prostatic Intraepithelial Neoplasia - surgery
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
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Summary:Prostatic adenocarcinoma (PAC) is a multifocal disease. In this study, we identified isolated and small foci of PAC (ISPAC) in radical prostatectomy specimens, described the histopathologic features, investigated their zonal distribution in the prostate and their relationship with large tumor nodules, and correlated the findings with those of preceding biopsy cores. One hundred and thirty radical prostatectomy specimens performed for PAC or for urothelial carcinoma of the urinary bladder with incidental PAC were reviewed for identification of ISPAC. Prostates were serially sectioned in the horizontal plane and submitted in toto for microscopic examination. ISPAC were defined as foci of PAC measuring less than 3 mm in maximum diameter. There were 461 ISPAC identified in 114 cases. They were distributed in the transitional zone (TZ) (18 foci), the apex (73 foci), the anterior horn of the non-TZ (NTZ) (118 foci), the base (8 foci), and the remaining NTZ (244 foci). ISPAC usually consisted of groups of small acini with a GS ranging from 2 to 7 (3 + 4). GSs of ISPAC consisted of single grade or two consecutive grades equal to or lower than those of the main PAC. ISPAC were more often located in close proximity to large tumor nodules. The number of ISPAC increased with the tumor volume up to 3 cm 3, then decreased as the PAC became more extensive (p value = 0.02, statistically significant). Prostates with NTZ PAC
ISSN:0344-0338
1618-0631
DOI:10.1078/0344-0338-00317