EEG Coherence Following Acute and Chronic Clozapine in Treatment-Resistant Schizophrenics

Electroencephalographic (EEG) coherence is an index of brain regional coupling that has been found to be abnormal in people with schizophrenia but has not been systematically examined in response to neuroleptics. EEG coherence in slow (delta and theta) frequencies was assessed in 17 treatment-resist...

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Bibliographic Details
Published in:Experimental and clinical psychopharmacology 2002-11, Vol.10 (4), p.435-444
Main Authors: Knott, Verner J, LaBelle, Alain, Jones, Barry, Mahoney, Colleen
Format: Article
Language:English
Subjects:
Adult
Antipsychotic Agents - therapeutic use
Brain Mapping
Clozapine
Clozapine - therapeutic use
Delta Rhythm
Drug Administration Schedule
Drug Therapy
Electroencephalography
Electroencephalography - drug effects
Electrophysiology
Female
Human
Humans
Male
Middle Aged
Physiological Correlates
Schizophrenia
Schizophrenia - drug therapy
Schizophrenia - physiopathology
Schizophrenic Psychology
Severity of Illness Index
Side Effects (Drug)
Signal Processing, Computer-Assisted - instrumentation
Theta Rhythm
Time Factors
Treatment Outcome
Treatment Resistant Disorders
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Summary:Electroencephalographic (EEG) coherence is an index of brain regional coupling that has been found to be abnormal in people with schizophrenia but has not been systematically examined in response to neuroleptics. EEG coherence in slow (delta and theta) frequencies was assessed in 17 treatment-resistant people with schizophrenia at baseline, 2 hr after their first oral dose (25 mg) and after 6 weeks of clozapine treatment. Compared with EEG norms, participants exhibited significant interhemispheric and intrahemispheric coherence abnormalities prior to treatment. Both acute and chronic treatments altered coherence but differed with respect to their relationship to symptom reduction and their ability to normalize or augment pretreatment abnormalities. Findings are discussed in relation to "disconnection" theories of schizophrenia.
ISSN:1064-1297
1936-2293
DOI:10.1037/1064-1297.10.4.435